Incidence and predictors of acute kidney injury associated with intravenous polymyxin B therapy

Christine J. Kubin, Tanya M. Ellman, Varun Phadke, Laura J. Haynes, David P. Calfee, Michael T. Yin

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Background: Increases in multidrug-resistance among gram-negative organisms have necessitated the use of polymyxins. To date, the incidence of acute kidney injury (AKI) associated with polymyxin B has not been evaluated using RIFLE criteria. Methods: Adult patients who received polymyxin B were retrospectively evaluated to determine the incidence of AKI during polymyxin B therapy using RIFLE criteria. Predictors of AKI were identified by comparing characteristics of patients with and without AKI. Results: A total of 73 patients were included. The incidence of AKI was 60%. Ten (14%) patients discontinued therapy due to nephrotoxicity. Median duration of polymyxin B was 11 days with a median cumulative dose of 18 mg/kg. Concomitant nephrotoxins were received in 69 (95%). Patients with AKI had a higher median cumulative dose (1578 mg vs. 800 mg; p = 0.02), a higher body mass index (BMI) (27.2 vs. 24.5 kg/m2; p = 0.03), and were more likely to receive vancomycin (82% vs. 55%; p = 0.03) compared to those without AKI. After controlling for polymyxin B duration, independent predictors of AKI were higher BMI and concomitant vancomycin. Conclusions: The incidence of AKI during polymyxin B therapy was 60%. Further studies are needed to define dosing parameters that maximize efficacy and minimize nephrotoxicity.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalJournal of Infection
Volume65
Issue number1
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • Nephrotoxicity
  • Polymyxin B
  • RIFLE

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