Incidence and mechanism of creatine kinase-MB enzyme elevation after coronary intervention with different devices

Annapoorna Kini, Subhash Kini, Jonathan D. Marmur, Tudor Bertea, George Dangas, Thomas P. Cocke, Samin K. Sharma

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The present study was conducted to evaluate the incidence of CK-MB elevation and to identify the possible mechanisms of CK-MB release after various coronary interventional devices. We prospectively studied 1,675 consecutive patients following various coronary interventions for CK-MB elevation, from January 1997 to February 1998 and followed them for in- hospital events. CK-MB elevation was detected in 313 patients (18.7%); with 1-3 x normal in 12.8%, 3-5 x normal in 3.5%, and >5 x normal in 2.4%. CK-MB elevation was more common after nonballoon devices (19.5% vs. 11.5% after balloon angioplasty; P < 0.01). Among the newer nonballoon devices, rotational atherectomy alone had a lower CK-MB elevation compared to stent- alone group (16.0% vs. 20.5%; P = 0.07). On univariate analysis, due to selective use of abciximab in high-risk coronary interventions, there was higher incidence of CK-MB elevation with abciximab (24.5% vs. 15.0% without abciximab; P < 0.01). Some kind of procedural complication was observed in 49% of the CK-MB elevation group, with side-branch closure being the most frequent (22.7%). In conclusion, CK-MB elevation is common after successful coronary interventions and is higher after nonballoon devices.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Volume48
Issue number2
DOIs
StatePublished - Oct 1999

Keywords

  • Abciximab
  • Angioplasty
  • CK-MB isoenzyme
  • Coronary intervention
  • New devices

Fingerprint

Dive into the research topics of 'Incidence and mechanism of creatine kinase-MB enzyme elevation after coronary intervention with different devices'. Together they form a unique fingerprint.

Cite this