Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: cooperative events in tumorigenesis.

Hilla Solomon, Ran Brosh, Yosef Buganim, Varda Rotter

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Since the discovery of the tumor suppressor p53 and the Ras oncogene, ample data have been accumulated, describing their aberrations in human cancer and their contribution to the multistep process of tumorigenesis. Several studies have also demonstrated that these dysregulated pathways cooperate to promote malignancy. Here we review recent studies on the cooperative molecular mechanisms by which p53 inactivation and oncogenic Ras converge to enhance tumorigenesis.

Original languageEnglish
Pages (from-to)448-454
Number of pages7
JournalDiscovery medicine
Volume9
Issue number48
StatePublished - May 2010

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