TY - JOUR
T1 - In vivo white light and contrast-enhanced vital-dye fluorescence imaging of Barrett's-related neoplasia in a single-endoscopic insertion
AU - Tang, Yubo
AU - Carns, Jennifer
AU - Polydorides, Alexandros D.
AU - Anandasabapathy, Sharmila
AU - Richards-Kortum, Rebecca R.
N1 - Publisher Copyright:
© The Authors.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - A modular video endoscope is developed to enable both white light imaging (WLI) and vital-dye fluorescence imaging (VFI) in a single-endoscopic insertion for the early detection of cancer in Barrett's esophagus (BE). We demonstrate that VFI can be achieved in conjunction with white light endoscopy, where appropriate white balance is used to correct for the presence of the emission filter. In VFI mode, a contrast enhancement feature is implemented in real time to further highlight glandular patterns in BE and related malignancies without introducing artifacts. In a pilot study, we demonstrate accurate correlation of images in two widefield modalities, with representative images showing the disruption and effacement of glandular architecture associated with cancer development in BE. VFI images of these alterations exhibit enhanced contrast when compared to WLI. Results suggest that the usefulness of VFI in the detection of BE-related neoplasia should be further evaluated in future in vivo studies.
AB - A modular video endoscope is developed to enable both white light imaging (WLI) and vital-dye fluorescence imaging (VFI) in a single-endoscopic insertion for the early detection of cancer in Barrett's esophagus (BE). We demonstrate that VFI can be achieved in conjunction with white light endoscopy, where appropriate white balance is used to correct for the presence of the emission filter. In VFI mode, a contrast enhancement feature is implemented in real time to further highlight glandular patterns in BE and related malignancies without introducing artifacts. In a pilot study, we demonstrate accurate correlation of images in two widefield modalities, with representative images showing the disruption and effacement of glandular architecture associated with cancer development in BE. VFI images of these alterations exhibit enhanced contrast when compared to WLI. Results suggest that the usefulness of VFI in the detection of BE-related neoplasia should be further evaluated in future in vivo studies.
KW - Barrett's esophagus
KW - contrast enhancement
KW - neoplasia
KW - single-endoscopic insertion
KW - vital-dye
UR - http://www.scopus.com/inward/record.url?scp=84983059475&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.21.8.086004
DO - 10.1117/1.JBO.21.8.086004
M3 - Article
C2 - 27533441
AN - SCOPUS:84983059475
SN - 1083-3668
VL - 21
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 8
M1 - 086004
ER -