In vivo observation of the pH alternation in mitochondria for various external stimuli

Lixia Cao; Zhensheng Zhao; Tao Zhang; Xudong Guo; Shuangqing Wang; Shayu Li; Yi Li; Guoqiang Yang

doi:10.1039/c5cc07118f

In vivo observation of the pH alternation in mitochondria for various external stimuli

Lixia Cao, Zhensheng Zhao, Tao Zhang, Xudong Guo, Shuangqing Wang, Shayu Li, Yi Li, Guoqiang Yang

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The pH of mitochondria (pH_m) has a close relationship with many biological processes. Here we developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value, which has excellent tolerance to environmental change. And Mito-pH-1 has been used for the first time to monitor the change of pH_m under temperature and H₂O₂ stimuli in living cells.

Original language	English
Pages (from-to)	17324-17327
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	97
DOIs	https://doi.org/10.1039/c5cc07118f
State	Published - 5 Oct 2015
Externally published	Yes

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title = "In vivo observation of the pH alternation in mitochondria for various external stimuli",

abstract = "The pH of mitochondria (pHm) has a close relationship with many biological processes. Here we developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value, which has excellent tolerance to environmental change. And Mito-pH-1 has been used for the first time to monitor the change of pHm under temperature and H2O2 stimuli in living cells.",

author = "Lixia Cao and Zhensheng Zhao and Tao Zhang and Xudong Guo and Shuangqing Wang and Shayu Li and Yi Li and Guoqiang Yang",

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T1 - In vivo observation of the pH alternation in mitochondria for various external stimuli

AU - Cao, Lixia

AU - Zhao, Zhensheng

AU - Zhang, Tao

AU - Guo, Xudong

AU - Wang, Shuangqing

AU - Li, Shayu

AU - Li, Yi

AU - Yang, Guoqiang

PY - 2015/10/5

Y1 - 2015/10/5

N2 - The pH of mitochondria (pHm) has a close relationship with many biological processes. Here we developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value, which has excellent tolerance to environmental change. And Mito-pH-1 has been used for the first time to monitor the change of pHm under temperature and H2O2 stimuli in living cells.

AB - The pH of mitochondria (pHm) has a close relationship with many biological processes. Here we developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value, which has excellent tolerance to environmental change. And Mito-pH-1 has been used for the first time to monitor the change of pHm under temperature and H2O2 stimuli in living cells.

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AN - SCOPUS:84948420090

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SP - 17324

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JO - Chemical Communications

JF - Chemical Communications

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ER -

In vivo observation of the pH alternation in mitochondria for various external stimuli

Abstract

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