In vivo non-invasive serial monitoring of fdg-pet progression and regression in a rabbit model of atherosclerosis

Stephen G. Worthley; Stephen G. Worthley; Zhuang Y. Zhang; Josef Machac; Gérard Helft; Cheuk Tang; Gary Y.H. Liew; Azfar G. Zaman; Matthew I. Worthley; Zahi A. Fayad; Monte S. Buchsbaum; Valentin Fuster; Juan J. Badimon

doi:10.1007/s10554-008-9377-2

In vivo non-invasive serial monitoring of fdg-pet progression and regression in a rabbit model of atherosclerosis

Stephen G. Worthley, Stephen G. Worthley, Zhuang Y. Zhang, Josef Machac, Gérard Helft, Cheuk Tang, Gary Y.H. Liew, Azfar G. Zaman, Matthew I. Worthley, Zahi A. Fayad, Monte S. Buchsbaum, Valentin Fuster, Juan J. Badimon

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Abstract

We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 ± 0.02 to 0.68 ± 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 ± 0.02 to 0.53 ± 0.02, P\0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model.

Original language	English
Pages (from-to)	251-257
Number of pages	7
Journal	International Journal of Cardiovascular Imaging
Volume	25
Issue number	3
DOIs	https://doi.org/10.1007/s10554-008-9377-2
State	Published - 2009

Keywords

Atherosclerosis
Fluorodeoxyglucose
Macrophages
PET

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Worthley, S. G., Worthley, S. G., Zhang, Z. Y., Machac, J., Helft, G., Tang, C., Liew, G. Y. H., Zaman, A. G., Worthley, M. I., Fayad, Z. A., Buchsbaum, M. S., Fuster, V., & Badimon, J. J. (2009). In vivo non-invasive serial monitoring of fdg-pet progression and regression in a rabbit model of atherosclerosis. International Journal of Cardiovascular Imaging, 25(3), 251-257. https://doi.org/10.1007/s10554-008-9377-2

@article{a61e6244b4834da5aa54231a8479e697,

title = "In vivo non-invasive serial monitoring of fdg-pet progression and regression in a rabbit model of atherosclerosis",

abstract = "We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 ± 0.02 to 0.68 ± 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 ± 0.02 to 0.53 ± 0.02, P\0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model.",

keywords = "Atherosclerosis, Fluorodeoxyglucose, Macrophages, PET",

author = "Worthley, {Stephen G.} and Worthley, {Stephen G.} and Zhang, {Zhuang Y.} and Josef Machac and G{\'e}rard Helft and Cheuk Tang and Liew, {Gary Y.H.} and Zaman, {Azfar G.} and Worthley, {Matthew I.} and Fayad, {Zahi A.} and Buchsbaum, {Monte S.} and Valentin Fuster and Badimon, {Juan J.}",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, B.V. 2008.",

year = "2009",

doi = "10.1007/s10554-008-9377-2",

language = "English",

volume = "25",

pages = "251--257",

journal = "International Journal of Cardiovascular Imaging",

issn = "1569-5794",

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Worthley, SG, Worthley, SG, Zhang, ZY, Machac, J, Helft, G, Tang, C, Liew, GYH, Zaman, AG, Worthley, MI, Fayad, ZA, Buchsbaum, MS, Fuster, V & Badimon, JJ 2009, 'In vivo non-invasive serial monitoring of fdg-pet progression and regression in a rabbit model of atherosclerosis', International Journal of Cardiovascular Imaging, vol. 25, no. 3, pp. 251-257. https://doi.org/10.1007/s10554-008-9377-2

TY - JOUR

T1 - In vivo non-invasive serial monitoring of fdg-pet progression and regression in a rabbit model of atherosclerosis

AU - Worthley, Stephen G.

AU - Zhang, Zhuang Y.

AU - Machac, Josef

AU - Helft, Gérard

AU - Tang, Cheuk

AU - Liew, Gary Y.H.

AU - Zaman, Azfar G.

AU - Worthley, Matthew I.

AU - Fayad, Zahi A.

AU - Buchsbaum, Monte S.

AU - Fuster, Valentin

AU - Badimon, Juan J.

N1 - Publisher Copyright: © Springer Science+Business Media, B.V. 2008.

PY - 2009

Y1 - 2009

N2 - We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 ± 0.02 to 0.68 ± 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 ± 0.02 to 0.53 ± 0.02, P\0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model.

AB - We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 ± 0.02 to 0.68 ± 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 ± 0.02 to 0.53 ± 0.02, P\0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model.

KW - Atherosclerosis

KW - Fluorodeoxyglucose

KW - Macrophages

KW - PET

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U2 - 10.1007/s10554-008-9377-2

DO - 10.1007/s10554-008-9377-2

M3 - Article

C2 - 18979182

AN - SCOPUS:67449094297

SN - 1569-5794

VL - 25

SP - 251

EP - 257

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

IS - 3

ER -

In vivo non-invasive serial monitoring of fdg-pet progression and regression in a rabbit model of atherosclerosis

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Keywords

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