IN-VIVO MORFOLOGISCH HERSENONDERZOEK BIJ PATIENTEN MET SCHIZOFRENIE

Translated title of the contribution: In vivo morphological brain research in schizophrenia

W. F.C. Baare, H. E. Hulshoff Pol, R. S. Kahn

Research output: Contribution to journalShort surveypeer-review

Abstract

In vivo morphological studies of the brain in schizophrenic patients, using computer tomography and magnetic resonance imaging, have provided information suggesting that schizophrenia is a brain disease. The most consistent findings of these studies are enlarged ventricles and volume reductions in the medial and lateral temporal lobes. Volume reductions of temporal cortex areas have been associated with the severity of positive symptoms such as delusions and hallucinations. Some of the morphological brain abnormalities may already be present before the onset of schizophrenia, and therefore may be directly related to the pathophysiology of the disease. In this article the relationship between in-vivo morphological findings and clinical variables, such as symptomatology, duration of illness and treatment response, will be discussed.

Translated title of the contributionIn vivo morphological brain research in schizophrenia
Original languageDutch
Pages (from-to)726-735
Number of pages10
JournalTijdschrift voor Psychiatrie
Volume36
Issue number10
StatePublished - 1994
Externally publishedYes

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