TY - JOUR
T1 - In vivo measurements of bone marrow cellularity using volume‐localized proton NMR spectroscopy
AU - Ballon, D.
AU - Jakubowski, A.
AU - Gabrilove, J.
AU - Graham, M. C.
AU - Zakowski, M.
AU - Sheridan, C.
AU - Koutcher, J. A.
PY - 1991/5
Y1 - 1991/5
N2 - Volume‐localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24‐h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P < 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases. © 1991 Academic Press, Inc.
AB - Volume‐localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24‐h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P < 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases. © 1991 Academic Press, Inc.
UR - http://www.scopus.com/inward/record.url?scp=0025906624&partnerID=8YFLogxK
U2 - 10.1002/mrm.1910190108
DO - 10.1002/mrm.1910190108
M3 - Article
C2 - 2046540
AN - SCOPUS:0025906624
SN - 0740-3194
VL - 19
SP - 85
EP - 95
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 1
ER -