In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

Oliver Jonas; Jeon Woong Kang; Surya P. Singh; Alex Lammers; Freddy T. Nguyen; Ramachandra R. Dasari; Peter T.C. So; Robert Langer; Michael J. Cima

doi:10.1039/c8an00913a

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

Oliver Jonas
, Jeon Woong Kang
, Surya P. Singh
, Alex Lammers
, Freddy T. Nguyen
, Ramachandra R. Dasari
, Peter T.C. So
, Robert Langer
, Michael J. Cima

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

Original language	English
Pages (from-to)	4836-4839
Number of pages	4
Journal	Analyst
Volume	143
Issue number	20
DOIs	https://doi.org/10.1039/c8an00913a
State	Published - 21 Oct 2018
Externally published	Yes

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10.1039/c8an00913a

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title = "In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy",

abstract = "We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.",

author = "Oliver Jonas and Kang, \{Jeon Woong\} and Singh, \{Surya P.\} and Alex Lammers and Nguyen, \{Freddy T.\} and Dasari, \{Ramachandra R.\} and So, \{Peter T.C.\} and Robert Langer and Cima, \{Michael J.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

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language = "English",

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AU - Jonas, Oliver

AU - Kang, Jeon Woong

AU - Singh, Surya P.

AU - Lammers, Alex

AU - Nguyen, Freddy T.

AU - Dasari, Ramachandra R.

AU - So, Peter T.C.

AU - Langer, Robert

AU - Cima, Michael J.

PY - 2018/10/21

Y1 - 2018/10/21

N2 - We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

AB - We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

UR - https://www.scopus.com/pages/publications/85054458833

U2 - 10.1039/c8an00913a

DO - 10.1039/c8an00913a

M3 - Article

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AN - SCOPUS:85054458833

SN - 0003-2654

VL - 143

SP - 4836

EP - 4839

JO - Analyst

JF - Analyst

IS - 20

ER -

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

Abstract

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