In-vivo biocompatibility evaluation of cross linked cellular and acellular bovine pericardium

Honjon Perme, A. K. Sharma, Naveen Kumar, Himani Singh, S. K. Maiti, Rajendra Singh

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7 Scopus citations


Fresh bovine pericardium procured from the local abattoir was cut into 2 cm × 2 cm size pieces and crosslinked with 1% solution of glutaraldehyde (GA), formaldehyde (FA), polyethylene glycol (PEG), hexamethylene di-isocyanate (HMDI) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). Other pieces were made acellular and then crosslinked with above chemical agents. In-vivo biocompatibility of the biomaterials was determined by subcutaneous implantation in rabbits. The implants were retrieved back on day 14, 30 and 90 post-implantation and subjected to macroscopic and microscopic evaluation. The host inflammatory response, neovascular tissue formation (fibroblasts, fine capillaries), deposition of neocollagen and penetration of host inflammatory responses in the grafted matrix were evaluated.

Original languageEnglish
Pages (from-to)658-661
Number of pages4
JournalIndian Journal of Animal Sciences
Issue number7
StatePublished - Jul 2009
Externally publishedYes


  • Biocompatibility
  • Bovine pericardium
  • Histopathology
  • Rabbits


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