TY - JOUR
T1 - In vivo and in vitro evaluation of the influence of aromatic retinoid RO 10-9359 and of its metabolite TMMP-RA, RO 10-1670 on polymorphonuclear leukocyte and lymphocyte functions in psoriatic subjects
AU - Marconi, M.
AU - Montagna, D.
AU - Alberini, C.
PY - 1984
Y1 - 1984
N2 - Lymphocytes and polymorphonuclear leukocytes functions of 10 psoriatic patients treated with aromatic retinoid RO 10-9359 were investigated. No changes of OK-T subpopulations were observed before, during (days 7, 14) and at the end of treatment (day 21). No alterations of PMNs functions investigated (chemotaxis, bactericidal activity, phagocytosis, NBT test reduction, respiratory burst) before, during and after treatment were observed. Lymphocyte responsiveness to polyclonal mitogens (PHA, ConA, PWM) were basically normal and decreased during treatment. No influences of the metabolite RO 10-1670 on PMNs chemotaxis in vitro could be shown.
AB - Lymphocytes and polymorphonuclear leukocytes functions of 10 psoriatic patients treated with aromatic retinoid RO 10-9359 were investigated. No changes of OK-T subpopulations were observed before, during (days 7, 14) and at the end of treatment (day 21). No alterations of PMNs functions investigated (chemotaxis, bactericidal activity, phagocytosis, NBT test reduction, respiratory burst) before, during and after treatment were observed. Lymphocyte responsiveness to polyclonal mitogens (PHA, ConA, PWM) were basically normal and decreased during treatment. No influences of the metabolite RO 10-1670 on PMNs chemotaxis in vitro could be shown.
UR - http://www.scopus.com/inward/record.url?scp=0021735875&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0021735875
SN - 0001-5555
VL - 64
SP - 47
EP - 49
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - SUPPL. 113
ER -