In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations

Savneet Kaur, Srivatsan Kidambi, Martí Ortega-Ribera, Le Thi Thanh Thuy, Natalia Nieto, Victoria C. Cogger, Wei Fen Xie, Frank Tacke, Jordi Gracia-Sancho

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modeling, therapeutic discovery, and clinical applicability.

Original languageEnglish
Pages (from-to)559-571
Number of pages13
JournalCellular and Molecular Gastroenterology and Hepatology
Issue number3
StatePublished - Jan 2023
Externally publishedYes


  • Bioengineering
  • Cirrhosis
  • Hepatic Sinusoid
  • Mechanobiology
  • NASH
  • Omics


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