In vitro interactions between antiretroviral protease inhibitors and artemisinin endoperoxides against Plasmodium falciparum

Zhengxiang He; Lili Chen; Jianlan You; Li Qin; Xiaoping Chen

doi:10.1016/j.ijantimicag.2009.09.016

In vitro interactions between antiretroviral protease inhibitors and artemisinin endoperoxides against Plasmodium falciparum

Zhengxiang He, Lili Chen, Jianlan You, Li Qin, Xiaoping Chen

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Antiretroviral protease inhibitors (APIs), which are effective at controlling the effects of human immunodeficiency virus (HIV) in patients, have also proven efficacious in inhibiting Plasmodium falciparum growth in vitro. Use of artemisinin-based combination therapies is being encouraged to reduce malaria mortality in areas of P. falciparum resistance to conventional antimalarial drugs. The aim of this study was to investigate drug interactions between HIV protease inhibitors and artemisinin drugs against malaria. In vitro cultures of P. falciparum provide a screen system for identifying and evaluating drug combinations. The derived isobolograms provide clear evidence of antagonistic interactions between artemisinin endoperoxides and several different APIs.

Original language	English
Pages (from-to)	191-193
Number of pages	3
Journal	International Journal of Antimicrobial Agents
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.ijantimicag.2009.09.016
State	Published - Feb 2010
Externally published	Yes

Keywords

Antimalarial
Antiretroviral protease inhibitors
Artemisinin endoperoxides
Drug interaction

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10.1016/j.ijantimicag.2009.09.016

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title = "In vitro interactions between antiretroviral protease inhibitors and artemisinin endoperoxides against Plasmodium falciparum",

abstract = "Antiretroviral protease inhibitors (APIs), which are effective at controlling the effects of human immunodeficiency virus (HIV) in patients, have also proven efficacious in inhibiting Plasmodium falciparum growth in vitro. Use of artemisinin-based combination therapies is being encouraged to reduce malaria mortality in areas of P. falciparum resistance to conventional antimalarial drugs. The aim of this study was to investigate drug interactions between HIV protease inhibitors and artemisinin drugs against malaria. In vitro cultures of P. falciparum provide a screen system for identifying and evaluating drug combinations. The derived isobolograms provide clear evidence of antagonistic interactions between artemisinin endoperoxides and several different APIs.",

keywords = "Antimalarial, Antiretroviral protease inhibitors, Artemisinin endoperoxides, Drug interaction",

author = "Zhengxiang He and Lili Chen and Jianlan You and Li Qin and Xiaoping Chen",

note = "Funding Information: Funding: This work was supported in part by a grant from the Bureau of Science and Technology of Guangzhou Municipality, China ( 2007Z3-E4131 ) as well as Science and Technology development funds of Guangzhou development district, China ( 2008Ss-P010 ). ",

year = "2010",

month = feb,

doi = "10.1016/j.ijantimicag.2009.09.016",

language = "English",

volume = "35",

pages = "191--193",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

publisher = "Elsevier",

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T1 - In vitro interactions between antiretroviral protease inhibitors and artemisinin endoperoxides against Plasmodium falciparum

AU - He, Zhengxiang

AU - Chen, Lili

AU - You, Jianlan

AU - Qin, Li

AU - Chen, Xiaoping

N1 - Funding Information: Funding: This work was supported in part by a grant from the Bureau of Science and Technology of Guangzhou Municipality, China ( 2007Z3-E4131 ) as well as Science and Technology development funds of Guangzhou development district, China ( 2008Ss-P010 ).

PY - 2010/2

Y1 - 2010/2

N2 - Antiretroviral protease inhibitors (APIs), which are effective at controlling the effects of human immunodeficiency virus (HIV) in patients, have also proven efficacious in inhibiting Plasmodium falciparum growth in vitro. Use of artemisinin-based combination therapies is being encouraged to reduce malaria mortality in areas of P. falciparum resistance to conventional antimalarial drugs. The aim of this study was to investigate drug interactions between HIV protease inhibitors and artemisinin drugs against malaria. In vitro cultures of P. falciparum provide a screen system for identifying and evaluating drug combinations. The derived isobolograms provide clear evidence of antagonistic interactions between artemisinin endoperoxides and several different APIs.

AB - Antiretroviral protease inhibitors (APIs), which are effective at controlling the effects of human immunodeficiency virus (HIV) in patients, have also proven efficacious in inhibiting Plasmodium falciparum growth in vitro. Use of artemisinin-based combination therapies is being encouraged to reduce malaria mortality in areas of P. falciparum resistance to conventional antimalarial drugs. The aim of this study was to investigate drug interactions between HIV protease inhibitors and artemisinin drugs against malaria. In vitro cultures of P. falciparum provide a screen system for identifying and evaluating drug combinations. The derived isobolograms provide clear evidence of antagonistic interactions between artemisinin endoperoxides and several different APIs.

KW - Antimalarial

KW - Antiretroviral protease inhibitors

KW - Artemisinin endoperoxides

KW - Drug interaction

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ER -

In vitro interactions between antiretroviral protease inhibitors and artemisinin endoperoxides against Plasmodium falciparum

Abstract

Keywords

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