In Vitro Inhibition of E Rosettes by Human Amniotic Fluid

To the Editor: Mouse amniotic fluid is reported to have an immunosuppressive effect on both humoral and cellular immune responses in mice.¹ The selective removal of major proteins by affinity chromatography suggested that the alpha fetoprotein is the immunosuppressive factor in mouse amniotic fluid. Satoh and his associates have recently demonstrated the inhibition of T rosettes by alpha fetoprotein isolated from human lung carcinoma.² Possible immunoregulatory activity of alpha fetoprotein may be important for protecting the histoincompatible embryo from immunologic attacks by the maternal immune system. In this communication we report the in vitro effect of human amniotic fluid on., No extract is available for articles shorter than 400 words.