In vitro infection of human primary adipose cells with HIV-1: A reassessment

Sandie Munier; Alejandra Borjabad; Morgane Lemaire; Virginie Mariot; Uriel Hazan

doi:10.1097/00002030-200311210-00019

In vitro infection of human primary adipose cells with HIV-1: A reassessment

Sandie Munier, Alejandra Borjabad, Morgane Lemaire, Virginie Mariot, Uriel Hazan

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

We reassessed the infection ability of human primary preadipocytes. The use of X4, R5 or VSV-G pseudotyped viral particles indicated that viral entry is the limiting step. However, transfection with HIV-1 receptors restored efficient infection. Analyses of CD4, CXCR4 and CCR5 expression on preadipocytes and adipocytes revealed that receptor co-expression levels did not permit HIV-1 entry into adipose cells from all biopsies tested. We concluded that adipose tissue cannot be infected with HIV-1 in vivo.

Original language	English
Pages (from-to)	2537-2539
Number of pages	3
Journal	AIDS
Volume	17
Issue number	17
DOIs	https://doi.org/10.1097/00002030-200311210-00019
State	Published - 21 Nov 2003
Externally published	Yes

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abstract = "We reassessed the infection ability of human primary preadipocytes. The use of X4, R5 or VSV-G pseudotyped viral particles indicated that viral entry is the limiting step. However, transfection with HIV-1 receptors restored efficient infection. Analyses of CD4, CXCR4 and CCR5 expression on preadipocytes and adipocytes revealed that receptor co-expression levels did not permit HIV-1 entry into adipose cells from all biopsies tested. We concluded that adipose tissue cannot be infected with HIV-1 in vivo.",

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AU - Munier, Sandie

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AU - Lemaire, Morgane

AU - Mariot, Virginie

AU - Hazan, Uriel

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AB - We reassessed the infection ability of human primary preadipocytes. The use of X4, R5 or VSV-G pseudotyped viral particles indicated that viral entry is the limiting step. However, transfection with HIV-1 receptors restored efficient infection. Analyses of CD4, CXCR4 and CCR5 expression on preadipocytes and adipocytes revealed that receptor co-expression levels did not permit HIV-1 entry into adipose cells from all biopsies tested. We concluded that adipose tissue cannot be infected with HIV-1 in vivo.

UR - https://www.scopus.com/pages/publications/1642369404

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ER -

In vitro infection of human primary adipose cells with HIV-1: A reassessment

Abstract

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