TY - JOUR
T1 - In vitro generation of renal tubular epithelial cells from fibroblasts
T2 - implications for precision and regenerative medicine in nephrology
AU - Wyatt, Christina M.
AU - Dubois, Nicole
N1 - Publisher Copyright:
© 2016 International Society of Nephrology
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Prior efforts to generate renal epithelial cells in vitro have relied on pluripotent or bone marrow–derived mesenchymal stem cells. A recent publication in Nature Cell Biology describes the generation of induced tubular epithelial cells from fibroblasts, potentially offering a novel platform for personalized drug toxicity screening and in vitro disease modeling. This report serves as a promising proof of principle study and opens future research directions, including the optimization of the reprogramming process, efficient translation to adult human fibroblasts, and the generation of highly specific functional renal cell types.
AB - Prior efforts to generate renal epithelial cells in vitro have relied on pluripotent or bone marrow–derived mesenchymal stem cells. A recent publication in Nature Cell Biology describes the generation of induced tubular epithelial cells from fibroblasts, potentially offering a novel platform for personalized drug toxicity screening and in vitro disease modeling. This report serves as a promising proof of principle study and opens future research directions, including the optimization of the reprogramming process, efficient translation to adult human fibroblasts, and the generation of highly specific functional renal cell types.
UR - http://www.scopus.com/inward/record.url?scp=85032641706&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2016.12.003
DO - 10.1016/j.kint.2016.12.003
M3 - Comment/debate
C2 - 28087003
AN - SCOPUS:85032641706
SN - 0085-2538
VL - 91
SP - 265
EP - 267
JO - Kidney International
JF - Kidney International
IS - 2
ER -