In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology

Christina M. Wyatt, Nicole Dubois

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

Prior efforts to generate renal epithelial cells in vitro have relied on pluripotent or bone marrow–derived mesenchymal stem cells. A recent publication in Nature Cell Biology describes the generation of induced tubular epithelial cells from fibroblasts, potentially offering a novel platform for personalized drug toxicity screening and in vitro disease modeling. This report serves as a promising proof of principle study and opens future research directions, including the optimization of the reprogramming process, efficient translation to adult human fibroblasts, and the generation of highly specific functional renal cell types.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalKidney International
Volume91
Issue number2
DOIs
StatePublished - 1 Feb 2017

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