TY - JOUR
T1 - In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles
AU - Hu, Xiaoke
AU - Cook, Sean
AU - Wang, Peng
AU - Hwang, Huey min
N1 - Funding Information:
This research was supported by the following grants: (1) U. S. Department of the Army Research and Development grant #W912HZ-04-2-0002 to Jackson State University (JSU); (2) NSF CREST Program with grant #HRD-0833178 for supporting Interdisciplinary Nanotoxicity Center; (3) and Department of Energy (DOE-MAT-SBI Program), grant #DE-FG36-05G085002 with subcontract# 07-08-001 to JSU.
PY - 2009/4/1
Y1 - 2009/4/1
N2 - The recent advances in nanotechnology and the corresponding popular usage of nanomaterials have resulted in uncertainties regarding their environmental impacts. In this study, we used a systematic approach to study and compare the in vitro cytotoxicity of selected engineered metal oxide nanoparticles to the test organisms - E. coli. Among the seven test nano-sized metal oxides, ZnO, CuO, Al2O3, La2O3, Fe2O3, SnO2 and TiO2, ZnO showed the lowest LD50 of 21.1 mg/L and TiO2 had the highest LD50 of 1104.8 mg/L. Data of 14C-glucose mineralization test paralleled the results of bacteria viability test. After regression calculation, the cytotoxicity was found to be correlated with cation charges (R2 = 0.9785). The higher the cation charge is, the lower the cytotoxicity of the nano-sized metal oxide becomes. To the best of our knowledge, this finding is the first report in nanotoxicology.
AB - The recent advances in nanotechnology and the corresponding popular usage of nanomaterials have resulted in uncertainties regarding their environmental impacts. In this study, we used a systematic approach to study and compare the in vitro cytotoxicity of selected engineered metal oxide nanoparticles to the test organisms - E. coli. Among the seven test nano-sized metal oxides, ZnO, CuO, Al2O3, La2O3, Fe2O3, SnO2 and TiO2, ZnO showed the lowest LD50 of 21.1 mg/L and TiO2 had the highest LD50 of 1104.8 mg/L. Data of 14C-glucose mineralization test paralleled the results of bacteria viability test. After regression calculation, the cytotoxicity was found to be correlated with cation charges (R2 = 0.9785). The higher the cation charge is, the lower the cytotoxicity of the nano-sized metal oxide becomes. To the best of our knowledge, this finding is the first report in nanotoxicology.
KW - Cytotoxicity
KW - LD
KW - Metal oxide nanoparticles
UR - https://www.scopus.com/pages/publications/61449116709
U2 - 10.1016/j.scitotenv.2009.01.033
DO - 10.1016/j.scitotenv.2009.01.033
M3 - Article
C2 - 19215968
AN - SCOPUS:61449116709
SN - 0048-9697
VL - 407
SP - 3070
EP - 3072
JO - Science of the Total Environment
JF - Science of the Total Environment
IS - 8
ER -