In vitro enhancement of natural and antibody-dependent lymphocyte-mediated cytotoxicity against tumor target cells by interferon

Michael J. Droller; Hakan Borg; Peter Perlmann

doi:10.1016/0008-8749(79)90335-6

In vitro enhancement of natural and antibody-dependent lymphocyte-mediated cytotoxicity against tumor target cells by interferon

Michael J. Droller
, Hakan Borg
, Peter Perlmann

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Interferon derived from virus-infected human leukocytes or fibroblasts was found to enhance spontaneous and antibody-dependent lymphocyte cytotoxicity against human target cell lines in vitro. The greater enhancement occurred with spontaneous lymphocyte cytotoxicity. Interferon exerted its effect directly on lymphocytes; no effect on target cells was seen. The mechanism of enhancement was unclear: It did not reflect antibody production or lymphocyte proliferation. Enhancement appeared to be immunologically nonspecific, but clarification of this effect awaits further study.

Original language	English
Pages (from-to)	248-260
Number of pages	13
Journal	Cellular Immunology
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(79)90335-6
State	Published - Oct 1979
Externally published	Yes

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title = "In vitro enhancement of natural and antibody-dependent lymphocyte-mediated cytotoxicity against tumor target cells by interferon",

abstract = "Interferon derived from virus-infected human leukocytes or fibroblasts was found to enhance spontaneous and antibody-dependent lymphocyte cytotoxicity against human target cell lines in vitro. The greater enhancement occurred with spontaneous lymphocyte cytotoxicity. Interferon exerted its effect directly on lymphocytes; no effect on target cells was seen. The mechanism of enhancement was unclear: It did not reflect antibody production or lymphocyte proliferation. Enhancement appeared to be immunologically nonspecific, but clarification of this effect awaits further study.",

author = "Droller, \{Michael J.\} and Hakan Borg and Peter Perlmann",

note = "Funding Information: {\textquoteright} Supported by Grant 0077 from the American Cancer Society (MJD) and Grant 36S-7377-09XA from the Swedish Cancer Society (PP). Reprint requests should be sent to MJD at Johns Hopkins Hospital.",

year = "1979",

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T1 - In vitro enhancement of natural and antibody-dependent lymphocyte-mediated cytotoxicity against tumor target cells by interferon

AU - Droller, Michael J.

AU - Borg, Hakan

AU - Perlmann, Peter

N1 - Funding Information: ’ Supported by Grant 0077 from the American Cancer Society (MJD) and Grant 36S-7377-09XA from the Swedish Cancer Society (PP). Reprint requests should be sent to MJD at Johns Hopkins Hospital.

PY - 1979/10

Y1 - 1979/10

N2 - Interferon derived from virus-infected human leukocytes or fibroblasts was found to enhance spontaneous and antibody-dependent lymphocyte cytotoxicity against human target cell lines in vitro. The greater enhancement occurred with spontaneous lymphocyte cytotoxicity. Interferon exerted its effect directly on lymphocytes; no effect on target cells was seen. The mechanism of enhancement was unclear: It did not reflect antibody production or lymphocyte proliferation. Enhancement appeared to be immunologically nonspecific, but clarification of this effect awaits further study.

AB - Interferon derived from virus-infected human leukocytes or fibroblasts was found to enhance spontaneous and antibody-dependent lymphocyte cytotoxicity against human target cell lines in vitro. The greater enhancement occurred with spontaneous lymphocyte cytotoxicity. Interferon exerted its effect directly on lymphocytes; no effect on target cells was seen. The mechanism of enhancement was unclear: It did not reflect antibody production or lymphocyte proliferation. Enhancement appeared to be immunologically nonspecific, but clarification of this effect awaits further study.

UR - https://www.scopus.com/pages/publications/0018736644

U2 - 10.1016/0008-8749(79)90335-6

DO - 10.1016/0008-8749(79)90335-6

M3 - Article

C2 - 487447

AN - SCOPUS:0018736644

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VL - 47

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JO - Cellular Immunology

JF - Cellular Immunology

IS - 2

ER -

In vitro enhancement of natural and antibody-dependent lymphocyte-mediated cytotoxicity against tumor target cells by interferon

Abstract

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