In vitro derived mouse A9 cell clones differing in malignancy: Analysis by somatic cell hybridization with YACIR lymphoma cell clones

G. B. Clements, E. M. Fenyo, G. Klein

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A culture of mouse A9 cells yielded clones of both high and low malignancy. Confirmation of the differences in malignancy of the clones was obtained after their hybridization with subclones of YACIR, a lymphoma induced by Moloney leukemia virus. Low malignant A9 clones suppressed the malignancy of the YACIR partner in the hybrids. Hybrids between a highly malignant A9 clone and two different clones of YACIR complemented to yield hybrids of reduced malignancy. No correlation was found between the malignancy of a particular A9 clone and its ability to produce a focus forming mouse C type virus.

Original languageEnglish
Pages (from-to)2004-2007
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number6
DOIs
StatePublished - 1976
Externally publishedYes

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