In vitro comparison of the neuromuscular antinicotinic and intestinal antimuscarinic effects of different nondepolarizing muscle relaxants

A. Torocsik, I. A. Chaudhry, K. Biro, H. Nagashima, M. Kinjo, D. Duncalf, R. Nagashima, F. F. Foldes, P. L. Goldiner, E. S. Vizi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The postsynaptic antimuscarinic properties of different nondepolarizing muscle relaxants were compared with their postsynaptic antinicotinic effect. d-Tubocurarine, pipecuronium and vecuronium were the most selective antagonists on postsynaptic nicotinic receptors. Gallamine, diadonium and Duador (RGH-4201) had relatively greater effect on postsynaptic muscarinic receptors. Therefore, much less side effect is expected to occur when pipecuronium, d-tubocurarine or vecuronium are used.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume299
StatePublished - 1989
Externally publishedYes

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