In vitro and in vivo plasticity of Pax5-deficient pre-B I cells

Antonius G. Rolink; Christoph Schaniel; Ludovica Bruno; Fritz Melchers

doi:10.1016/S0165-2478(02)00016-0

In vitro and in vivo plasticity of Pax5-deficient pre-B I cells

Antonius G. Rolink, Christoph Schaniel, Ludovica Bruno, Fritz Melchers

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In mice deficient for the transcription factor Pax-5, B cell development is blocked at the pre-B I cell stage. Like wild type, Pax-5^-/- pre-B I cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild type in vitro grown counterparts, Pax-5^-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoeitic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax-5^-/- pre-B I cells.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Immunology Letters
Volume	82
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-2478(02)00016-0
State	Published - 3 Jun 2002
Externally published	Yes

Keywords

Cells
Mice
Pax-5

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10.1016/S0165-2478(02)00016-0

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title = "In vitro and in vivo plasticity of Pax5-deficient pre-B I cells",

abstract = "In mice deficient for the transcription factor Pax-5, B cell development is blocked at the pre-B I cell stage. Like wild type, Pax-5-/- pre-B I cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild type in vitro grown counterparts, Pax-5-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoeitic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax-5-/- pre-B I cells.",

keywords = "Cells, Mice, Pax-5",

author = "Rolink, {Antonius G.} and Christoph Schaniel and Ludovica Bruno and Fritz Melchers",

note = "Funding Information: The Basel Institute for Immunology was founded and is supported by F. Hoffmann-La Roche Ltd., Basel, Switzerland.",

year = "2002",

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doi = "10.1016/S0165-2478(02)00016-0",

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T1 - In vitro and in vivo plasticity of Pax5-deficient pre-B I cells

AU - Rolink, Antonius G.

AU - Schaniel, Christoph

AU - Bruno, Ludovica

AU - Melchers, Fritz

N1 - Funding Information: The Basel Institute for Immunology was founded and is supported by F. Hoffmann-La Roche Ltd., Basel, Switzerland.

PY - 2002/6/3

Y1 - 2002/6/3

N2 - In mice deficient for the transcription factor Pax-5, B cell development is blocked at the pre-B I cell stage. Like wild type, Pax-5-/- pre-B I cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild type in vitro grown counterparts, Pax-5-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoeitic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax-5-/- pre-B I cells.

AB - In mice deficient for the transcription factor Pax-5, B cell development is blocked at the pre-B I cell stage. Like wild type, Pax-5-/- pre-B I cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild type in vitro grown counterparts, Pax-5-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoeitic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax-5-/- pre-B I cells.

KW - Cells

KW - Mice

KW - Pax-5

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DO - 10.1016/S0165-2478(02)00016-0

M3 - Article

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AN - SCOPUS:0037013736

SN - 0165-2478

VL - 82

SP - 35

EP - 40

JO - Immunology Letters

JF - Immunology Letters

IS - 1-2

ER -

In vitro and in vivo plasticity of Pax5-deficient pre-B I cells

Abstract

Keywords

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