In vitro and in vivo plasticity of Pax5-deficient pre-B I cells

Antonius G. Rolink, Christoph Schaniel, Ludovica Bruno, Fritz Melchers

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


In mice deficient for the transcription factor Pax-5, B cell development is blocked at the pre-B I cell stage. Like wild type, Pax-5-/- pre-B I cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild type in vitro grown counterparts, Pax-5-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoeitic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax-5-/- pre-B I cells.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalImmunology Letters
Issue number1-2
StatePublished - 3 Jun 2002
Externally publishedYes


  • Cells
  • Mice
  • Pax-5


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