In vitro activity of tigecycline and other 13 antimicrobial agents against multidrug-resistant bacteria

Xiao Jiang Zhang, Ying Chun Xu, Ying Yuan, Xiu Li Xie, Hong Tao Dou, Ying Zhao, Peng Wang, Ren Yuan Zhu, Hui Wang, Min Jun Chen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: To evaluate the in vitro activity of tigecycline against multidrug-resistant (MDR) bacteria. Methods: The minimum inhibitory concentrations (MICs) of tigecycline against 214 MDR clinical isolates from Peking Union Medical College Hospital in 2004, 2006 and 2008 were determined and compared with other 13 antimicrobial agents using broth microdilution method. Data were analyzed using WHONET 5.4 software. Results: Tigecycline, vancomycin and linezolid showed excellent activity against MDR MRSA. Tigecycline and linezolid were the most active agents against MDR Enterococcus (100% susceptible), followed by vancomycin (93.1%). Tigecycline and linezolid were the most active agents against the 2 strains of vancomycin-resistant MDR E. faecium, with MIC90 values of 0.064 mg/L and 1 mg/L. The susceptibility of MDR A. baumannii to tigecycline was 97.3%. MIC90 value was 2 mg/L. The most active agent against 16 strains of meropenem-resistant MDR A. baumannii was tigecycline (100%). MIC90 value was 2 mg/L. All ESBLs-producing E. coli and K. pneumoniae isolates were susceptible to tigecycline and meropenem, but MIC90 values of tigecycline were higher than those of meropenem. The susceptibility of MDR Enterobacter to tigecycline was 86.5%. MIC90 value was 4 mg/L. Conclusions: Tigecycline is a novel broad spectrum antibiotic with good in vitro activity against the common MDR, including both gram-positive and gram-negative pathogens.

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalChinese Journal of Infection and Chemotherapy
Volume9
Issue number5
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • Antimicro
  • Bial agents
  • Multidrug-resistant
  • Tigecycline

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