In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections

Bruce E. Reidenberg; Stephen G. Jenkins; Jared L. Crandon; Elizabeth Hurlburt; Xing Tan; Paul R. Rhomberg; S. J.Ryan Arends; Antony Pfaffle

doi:10.1128/aac.00381-24

In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections

Bruce E. Reidenberg, Stephen G. Jenkins, Jared L. Crandon, Elizabeth Hurlburt, Xing Tan, Paul R. Rhomberg, S. J.Ryan Arends, Antony Pfaffle

Research output: Contribution to journal › Article › peer-review

Abstract

Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC₅₀/MIC₉₀ of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	68
Issue number	7
DOIs	https://doi.org/10.1128/aac.00381-24
State	Published - Jul 2024
Externally published	Yes

Keywords

CLABSI
Candida auris
catheter-related bloodstream infection
taurolidine

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title = "In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections",

abstract = "Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.",

keywords = "CLABSI, Candida auris, catheter-related bloodstream infection, taurolidine",

author = "Reidenberg, {Bruce E.} and Jenkins, {Stephen G.} and Crandon, {Jared L.} and Elizabeth Hurlburt and Xing Tan and Rhomberg, {Paul R.} and Arends, {S. J.Ryan} and Antony Pfaffle",

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doi = "10.1128/aac.00381-24",

language = "English",

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T1 - In vitro activity of taurolidine against clinical Candida auris isolates

T2 - relevance to catheter-related bloodstream infections

AU - Reidenberg, Bruce E.

AU - Jenkins, Stephen G.

AU - Crandon, Jared L.

AU - Hurlburt, Elizabeth

AU - Tan, Xing

AU - Rhomberg, Paul R.

AU - Arends, S. J.Ryan

AU - Pfaffle, Antony

PY - 2024/7

Y1 - 2024/7

N2 - Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.

AB - Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.

KW - CLABSI

KW - Candida auris

KW - catheter-related bloodstream infection

KW - taurolidine

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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ER -

In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections

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Keywords

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