In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin

Andrea Endimiani; Gopi Patel; Kristine M. Hujer; Mahesh Swaminathan; Federico Perez; Louis B. Rice; Michael R. Jacobs; Robert A. Bonomo

doi:10.1128/AAC.01235-09

In vitro activity of fosfomycin against bla_KPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin

Andrea Endimiani, Gopi Patel, Kristine M. Hujer, Mahesh Swaminathan, Federico Perez, Louis B. Rice, Michael R. Jacobs, Robert A. Bonomo

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Abstract

In vitro activity of fosfomycin was evaluated against 68 bla _KPC-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC_50/90 of 16/64 μg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC_50/90 of 32/128 μg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.

Original language	English
Pages (from-to)	526-529
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	54
Issue number	1
DOIs	https://doi.org/10.1128/AAC.01235-09
State	Published - Jan 2010

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title = "In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin",

abstract = "In vitro activity of fosfomycin was evaluated against 68 bla KPC-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC50/90 of 16/64 μg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC50/90 of 32/128 μg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.",

author = "Andrea Endimiani and Gopi Patel and Hujer, {Kristine M.} and Mahesh Swaminathan and Federico Perez and Rice, {Louis B.} and Jacobs, {Michael R.} and Bonomo, {Robert A.}",

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T1 - In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin

AU - Endimiani, Andrea

AU - Patel, Gopi

AU - Hujer, Kristine M.

AU - Swaminathan, Mahesh

AU - Perez, Federico

AU - Rice, Louis B.

AU - Jacobs, Michael R.

AU - Bonomo, Robert A.

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AB - In vitro activity of fosfomycin was evaluated against 68 bla KPC-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC50/90 of 16/64 μg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC50/90 of 32/128 μg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.

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In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin

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In vitro activity of fosfomycin against bla_KPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin