In situ hybridization for gene mapping

P. M. Price, K. Hirschhorn

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The techniques that have been described for gene mapping have proven to be invaluable aids to the cytogeneticist. They are not, however, without limitations. In situ hybridization is potentially the most powerful technique available for gene mapping and has already proven useful for these studies. By a combination of the isolation of pure protein specific mRNA and the synthesis of high specific activity radioactive cDNA to it, this procedure should rapidly increase knowledge of gene locations, linkages, and possibly even heretofore undetectable minor deletions.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalCytogenetics and Cell Genetics
Volume14
Issue number3-6
DOIs
StatePublished - 1975
Externally publishedYes

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