In silico model-based inference: An emerging approach for inverse problems in engineering better medicines

David J. Klinke, Marc R. Birtwistle

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Identifying the network of biochemical interactions that underpin disease pathophysiology is a key hurdle in drug discovery. While many components involved in these biological processes are identified, how components organize differently in health and disease remains unclear. In chemical engineering, mechanistic modeling provides a quantitative framework to capture our understanding of a reactive system and test this knowledge against data. Here, we describe an emerging approach to test this knowledge against data that leverages concepts from probability, Bayesian statistics, and chemical kinetics by focusing on two related inverse problems. The first problem is to identify the causal structure of the reaction network, given uncertainty as to how the reactive components interact. The second problem is to identify the values of the model parameters, when a network is known a priori.

Original languageEnglish
Pages (from-to)14-24
Number of pages11
JournalCurrent Opinion in Chemical Engineering
Volume10
DOIs
StatePublished - 13 Aug 2015

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