Improving the response to hepatitis B vaccine

Alan S. Rosman, Charles S. Lieber

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Although vaccines against hepatitis B virus have been a major advance in eradicating liver disease caused by hepatitis B infection, certain populations fail to mount an adequate protective immune response after vaccination. These include patients with chronic renal failure and alcoholism. Nonresponsiveness in healthy patients has been associated with smoking, increased age, excessive body mass, and certain HLA types or haplotypes. Some ways to improve vaccine responsiveness include increasing the dose and frequency of hepatitis B vaccine, giving booster doses, administering the vaccine as an intradermal injection, and using immunostimulants concomitantly.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalInfections in Medicine
Issue number3
StatePublished - 1999


  • Hepatitis B virus (HBV)
  • Immunization
  • Liver disease
  • Renal failure
  • Vaccines


Dive into the research topics of 'Improving the response to hepatitis B vaccine'. Together they form a unique fingerprint.

Cite this