Improvement of hepatopulmonary syndrome after transjugular intrahepatic portasystemic shunting: Case report and review of literature

Anil S. Paramesh, Sohail Z. Husain, Benjamin Shneider, Jeffrey Guller, Ikbal Tokat, Gabriel E. Gondolesi, Susan Moyer, Sukru Emre

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

The hepatopulmonary syndrome has been described in as many as 5-29% of patients with liver disease. Patients with this syndrome may suffer from chronic hypoxemia, and mortality rates of liver patients with this syndrome are as high as 41%. Early diagnosis of such patients is essential. Currently, liver transplantation is the only effective therapy for such patients, and reversal of this syndrome is seen in up to 80% of patients post-transplant. Transjugular intrahepatic portasystemic shunting (TIPS) as a therapeutic maneuver for this syndrome has been described in five patients to date with mixed results. Reduction in portal hypertension with consequent redistribution of blood flow and altered synthesis of vasodilatory chemicals have been postulated to help resolve this disease. In this report, we describe an 11-yr-old female with biliary atresia and hepatopulmonary syndrome. Her disease was complicated with recurrent variceal bleeding. TIPS achieved a therapeutic response of both her bleeding and respiratory complications.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalPediatric Transplantation
Volume7
Issue number2
DOIs
StatePublished - Apr 2003

Keywords

  • Biliary atresia
  • Hepatopulmonary syndrome
  • Liver disease
  • Transjugular intrahepatic portasystemic shunting

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