Improvement in Serum Albumin With Adequate Hemodialysis

Jerrilynn D. Burrowes, Tracy A. Lyons, Allen M. Kaufman, Nathan W. Levin

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


■ Objective: To determine the effects of adequate hemodialysis on serum albumin in patients undergoing maintenance hemodialysis. ■ Design: Cohort analytical study. ■ Setting: Hospital-based dialysis unit. ■ Patients: All patients entering the hemodialysis program between December 1990 and June 1992 were selected for the study, and their charts were reviewed (n = 213). Patients in the program for more than 3 months and those who had serum albumin less than or equal to 35.0 g/L (3.50 g/dL) were included. Of the charts reviewed, 66 patients met the inclusion criteria: 28 transferred from other units (group 1), 30 initiated maintenance hemodialysis in the unit (group 2), and 8 received intradialytic parenteral nutrition (IDPN). ■ Main outcome measure: Blood samples were obtained each month to determine the change in serum albumin concentration. ■ Results: Serum albumin increased significantly (P < .0001) in 21 patients in group 1 (mean time, 8.5 ± 4.5 months) and in 23 patients in group 2 (mean time, 10.1 ± 4.2 months), with mean delivered Kt/V between 1.2 and 1.4 and mean protein catabolic rate (PCR) between 1.0 and 1.2 g/kg/d. Demographic data between the two groups were not statistically significant except for years on dialysis. Patients on IDPN (mean time, 5.75 ± 2.2 months) showed a significant increase in serum albumin (P < .01) with adequate hemodialysis and protein intake. ■ Conclusion: In hemodialysis patients with a low serum albumin concentration, the provision of adequate hemodialysis, protein, and calorie intake may result in an increase in serum albumin and PCR.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalJournal of Renal Nutrition
Issue number4
StatePublished - 1993
Externally publishedYes


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