TY - JOUR
T1 - Improved memory for reward cues following acute buprenorphine administration in humans
AU - Syal, Supriya
AU - Ipser, Jonathan
AU - Terburg, David
AU - Solms, Mark
AU - Panksepp, Jaak
AU - Malcolm-Smith, Susan
AU - Bos, Peter A.
AU - Montoya, Estrella R.
AU - Stein, Dan J.
AU - van Honk, Jack
N1 - Publisher Copyright:
© 2015 .
PY - 2015/3/1
Y1 - 2015/3/1
N2 - In rodents, there is abundant evidence for the involvement of the opioid system in the processing of reward cues, but this system has remained understudied in humans. In humans, the happy facial expression is a pivotal reward cue. Happy facial expressions activate the brain's reward system and are disregarded by subjects scoring high on depressive mood who are low in reward drive. We investigated whether a single 0.2. mg administration of the mixed mu-opioid agonist/kappa-antagonist, buprenorphine, would influence short-term memory for happy, angry or fearful expressions relative to neutral faces. Healthy human subjects (n38) participated in a randomized placebo-controlled within-subject design, and performed an emotional face relocation task after administration of buprenorphine and placebo. We show that, compared to placebo, buprenorphine administration results in a significant improvement of memory for happy faces. Our data demonstrate that acute manipulation of the opioid system by buprenorphine increases short-term memory for social reward cues.
AB - In rodents, there is abundant evidence for the involvement of the opioid system in the processing of reward cues, but this system has remained understudied in humans. In humans, the happy facial expression is a pivotal reward cue. Happy facial expressions activate the brain's reward system and are disregarded by subjects scoring high on depressive mood who are low in reward drive. We investigated whether a single 0.2. mg administration of the mixed mu-opioid agonist/kappa-antagonist, buprenorphine, would influence short-term memory for happy, angry or fearful expressions relative to neutral faces. Healthy human subjects (n38) participated in a randomized placebo-controlled within-subject design, and performed an emotional face relocation task after administration of buprenorphine and placebo. We show that, compared to placebo, buprenorphine administration results in a significant improvement of memory for happy faces. Our data demonstrate that acute manipulation of the opioid system by buprenorphine increases short-term memory for social reward cues.
KW - Happy facial expression
KW - Opioids
KW - Reward
KW - Short term memory
UR - http://www.scopus.com/inward/record.url?scp=84922794948&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2014.11.009
DO - 10.1016/j.psyneuen.2014.11.009
M3 - Article
C2 - 25569708
AN - SCOPUS:84922794948
SN - 0306-4530
VL - 53
SP - 10
EP - 15
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -