Improved grasp function with transcranial direct current stimulation in chronic spinal cord injury

Mar Cortes, Ana Heloisa Medeiros, Aasta Gandhi, Peter Lee, Hermano Igo Krebs, Gary Thickbroom, Dylan Edwards

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

BACKGROUND: Recovering hand function has important implications for improving independence of patients with tetraplegia after traumatic spinal cord injury (SCI). Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation technique that has potential to improve motor function. OBJECTIVE: To investigate the effects of one session of 1mA, 2mA, and sham anodal tDCS (a-tDCS) in the upper extremity (hand) motor performance (grasp and lease) in patients with chronic cervical SCI. METHODS: Eleven participants with incomplete SCI were randomized to receive 20 minutes of 1mA, 2mA, or sham stimulation over the targeted motor cortex over three separated sessions. Hand motor performance was measured by a hand robotic evaluation (kinematics) and the Box and Blocks (BB) test before and after the stimulation period. RESULTS: A significant improvement on the grasp mean to peak speed ratio (GMP) was observed in the 2mA group (pre: 0.38±0.02; post: 0.43±0.03; mean±SEM; p=0.031). There was no statistically significant difference in BB test results, however the 2mA intervention showed a positive trend for improvement. CONCLUSIONS: A single session of 2mA of a-tDCS showed gains in hand motor function in patients with chronic SCI that were not observed in functional clinical scales. The use of robotic kinematics showed promising results in assessing small changes in motor performance. Further studies are necessary to determine whether tDCS can be an effective long-term rehabilitation strategy for individuals with SCI.

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalNeuroRehabilitation
Volume41
Issue number1
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Hand robot
  • Motor recovery
  • Spinal cord injury
  • TDCS

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