Improved CSF classification and lesion detection in MR brain images with Multiple Sclerosis

Yulian Wolff, Shmuel Miron, Anat Achiron, Hayit Greenspan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


The study deals with the challenging task of automatic segmentation of MR brain images with multiple sclerosis lesions (MSL). Multi-Channel data is used, including "fast fluid attenuated inversion recovery" (fast FLAIR or FF), and statistical modeling tools are developed, in order to improve cerebrospinal fluid (CSF) classification and to detect MSL. Two new concepts are proposed for use within an EM framework. The first concept is the integration of prior knowledge as it relates to tissue behavior in different MRI modalities, with special attention given to the FF modality. The second concept deals with running the algorithm on a subset of the input that is most likely to be noise- and artifact-free data. This enables a more reliable learning of the Gaussian mixture model (GMM) parameters for brain tissue statistics. The proposed method focuses on the problematic CSF intensity distribution, which is a key to improved overall segmentation and lesion detection. A level-set based active contour stage is performed for lesion delineation, using gradient and shape properties combined with previously learned region intensity statistics. In the proposed scheme there is no need for preregistration of an atlas, a common characteristic in brain segmentation schemes. Experimental results on real data are presented.

Original languageEnglish
Title of host publicationMedical Imaging 2007
Subtitle of host publicationImage Processing
EditionPART 2
StatePublished - 2007
Externally publishedYes
EventMedical Imaging 2007: Image Processing - San Diego, CA, United States
Duration: 18 Feb 200720 Feb 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 2
ISSN (Print)1605-7422


ConferenceMedical Imaging 2007: Image Processing
Country/TerritoryUnited States
CitySan Diego, CA


  • Active contours
  • Brain
  • CSF
  • EM
  • Fast-flair
  • GMM
  • MRI
  • Multiple sclerosis
  • Segmentation
  • Statistical methods

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