Impaired platelet-connective-tissue reaction in man after aspirin ingestion.

H. J. Weiss; L. M. Aledort

Impaired platelet-connective-tissue reaction in man after aspirin ingestion.

H. J. Weiss, L. M. Aledort

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

263 Scopus citations

Original language	English
Pages (from-to)	495-497
Number of pages	3
Journal	The Lancet
Volume	2
Issue number	7514
State	Published - 2 Sep 1967

Cite this

@article{968d15fdacec446da9268d1d82fec2e7,

title = "Impaired platelet-connective-tissue reaction in man after aspirin ingestion.",

author = "Weiss, {H. J.} and Aledort, {L. M.}",

note = "Funding Information: release of platelet A.D.P. is entirely speculative at present. The decrease in platelet A.T.P., from which A.D.P. is pre- sumably derived, was not statistically significant when compared with the control group, and platelet A.T.P.ase remained unchanged. Although aspirin has been shown to uncouple oxidative phosphorylation,13 thereby reducing the available A.T.P., in many in-vitro cell systems, this has been difficult to demonstrate after its administration to the whole animaL1 The ability of aspirin to inhibit the platelet connective-tissue reaction after its oral administration in man is similar to the effect which Mustard et al. have demonstrated for a variety of anti-inflammatory agents tested in vitro,14 and which Evans et al. have reported after their administration to rabbits.15 The results suggest that these agents may have antithrombotic properties. We wish to thank Mr. John Rogers and Mrs. Sadie Chu for their technical assistance. This study was supported in part by Public Health Service grant HE 10905 and contract PH 43-67-1359, and the Albert A. List, Frederick Machlin and Anna Ruth Lowenberg Fund. Requests for reprints should be addressed to H. J. W., Depart- ment of Hematology, Mount Sinai Hospital, 100th Street and Fifth Avenue, New York, N.Y. 10029, U.S.A. HARVEY J. WEISS, M.D. Harvard LOUIS M. ALEDORT M.D. Albert Einstein Funding Information: Further work on the detailed pathogenesis of these lesions and on the role of mechanical, familial, and bio- chemical factors in their development is in progress. This work is part of a wider programme of elephant research initiated by Dr. R. M. Laws. We would like to thank him for his encouragement and support. We also thank the trustees of both Kenya and Uganda National Parks, Game Management (Uganda) Ltd., and Wildlife Services Ltd., of Nairobi, and in particular Mr. Ian Parker, without whose kind cooperation this study would not be possible. We should also like to acknowledge the help and advice of Prof. R. A. McCance, Prof. M. S. R. Hutt, and Prof. C. V. Harrison. This section of the project was financed by the Royal Society and the atherosclerosis project of the Albany Medical College Department of Pathology, Albany, New York. Requests for reprints should be addressed to K. McC., Medical Research Medical Council, Research 5 Shaftesbury Road, Cambridge.",

year = "1967",

month = sep,

day = "2",

language = "English",

volume = "2",

pages = "495--497",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Ltd.",

number = "7514",

}

TY - JOUR

T1 - Impaired platelet-connective-tissue reaction in man after aspirin ingestion.

AU - Weiss, H. J.

AU - Aledort, L. M.

N1 - Funding Information: release of platelet A.D.P. is entirely speculative at present. The decrease in platelet A.T.P., from which A.D.P. is pre- sumably derived, was not statistically significant when compared with the control group, and platelet A.T.P.ase remained unchanged. Although aspirin has been shown to uncouple oxidative phosphorylation,13 thereby reducing the available A.T.P., in many in-vitro cell systems, this has been difficult to demonstrate after its administration to the whole animaL1 The ability of aspirin to inhibit the platelet connective-tissue reaction after its oral administration in man is similar to the effect which Mustard et al. have demonstrated for a variety of anti-inflammatory agents tested in vitro,14 and which Evans et al. have reported after their administration to rabbits.15 The results suggest that these agents may have antithrombotic properties. We wish to thank Mr. John Rogers and Mrs. Sadie Chu for their technical assistance. This study was supported in part by Public Health Service grant HE 10905 and contract PH 43-67-1359, and the Albert A. List, Frederick Machlin and Anna Ruth Lowenberg Fund. Requests for reprints should be addressed to H. J. W., Depart- ment of Hematology, Mount Sinai Hospital, 100th Street and Fifth Avenue, New York, N.Y. 10029, U.S.A. HARVEY J. WEISS, M.D. Harvard LOUIS M. ALEDORT M.D. Albert Einstein Funding Information: Further work on the detailed pathogenesis of these lesions and on the role of mechanical, familial, and bio- chemical factors in their development is in progress. This work is part of a wider programme of elephant research initiated by Dr. R. M. Laws. We would like to thank him for his encouragement and support. We also thank the trustees of both Kenya and Uganda National Parks, Game Management (Uganda) Ltd., and Wildlife Services Ltd., of Nairobi, and in particular Mr. Ian Parker, without whose kind cooperation this study would not be possible. We should also like to acknowledge the help and advice of Prof. R. A. McCance, Prof. M. S. R. Hutt, and Prof. C. V. Harrison. This section of the project was financed by the Royal Society and the atherosclerosis project of the Albany Medical College Department of Pathology, Albany, New York. Requests for reprints should be addressed to K. McC., Medical Research Medical Council, Research 5 Shaftesbury Road, Cambridge.

PY - 1967/9/2

Y1 - 1967/9/2

UR - http://www.scopus.com/inward/record.url?scp=0014190795&partnerID=8YFLogxK

M3 - Article

C2 - 4166411

AN - SCOPUS:0014190795

SN - 0140-6736

VL - 2

SP - 495

EP - 497

JO - The Lancet

JF - The Lancet

IS - 7514

ER -