Impaired immune function and identification of polybrominated biphenyls (PBB) in blood compartments of exposed michigan dairy farmers and chemical workers

J. George Bekesi; John Roboz; H. A. Anderson; Julia P. Roboz; A. S. Fischbein; I. J. Selikoff; J. F. Holland

doi:10.3109/01480547908993189

Impaired immune function and identification of polybrominated biphenyls (PBB) in blood compartments of exposed michigan dairy farmers and chemical workers

J. George Bekesi
, John Roboz
, H. A. Anderson
, Julia P. Roboz
, A. S. Fischbein
, I. J. Selikoff
, J. F. Holland

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In 1973 PBB's were accidentally mixed into animal feed, resulting in marked toxic effects. Meat and dairy products were widely consumed in Michigan. To determine the impact of PBB's, 55 exposed Michigan farm residents, 11 Michigan chemical workers and 46 non-exposed Wisconsin farmers were examined. Abnormalities included decreased number of T-lymphocytes with concomitant increase of lymphocytes with no detectable surface markers, "null cells" and altered lymphocyte function. Data obtained from skin testing using standard recall antigens, showed no consistent correlation between the delayed cutaneous hypersensi-tivity response and the impaired lymphocyte function. PBB (hexa) in separated white blood cells and red cells was positively identified and quantified by gas chromatography-mass spectrometry. PBB and immu-nological abnormalities were not detected in non-exposed Wisconsin dairy farm residents.

Original language	English
Pages (from-to)	179-191
Number of pages	13
Journal	Drug and Chemical Toxicology
Volume	2
Issue number	1-2
DOIs	https://doi.org/10.3109/01480547908993189
State	Published - 1979

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@article{74b542d558834315a173f900590cac98,

title = "Impaired immune function and identification of polybrominated biphenyls (PBB) in blood compartments of exposed michigan dairy farmers and chemical workers",

abstract = "In 1973 PBB's were accidentally mixed into animal feed, resulting in marked toxic effects. Meat and dairy products were widely consumed in Michigan. To determine the impact of PBB's, 55 exposed Michigan farm residents, 11 Michigan chemical workers and 46 non-exposed Wisconsin farmers were examined. Abnormalities included decreased number of T-lymphocytes with concomitant increase of lymphocytes with no detectable surface markers, {"}null cells{"} and altered lymphocyte function. Data obtained from skin testing using standard recall antigens, showed no consistent correlation between the delayed cutaneous hypersensi-tivity response and the impaired lymphocyte function. PBB (hexa) in separated white blood cells and red cells was positively identified and quantified by gas chromatography-mass spectrometry. PBB and immu-nological abnormalities were not detected in non-exposed Wisconsin dairy farm residents.",

author = "Bekesi, \{J. George\} and John Roboz and Anderson, \{H. A.\} and Roboz, \{Julia P.\} and Fischbein, \{A. S.\} and Selikoff, \{I. J.\} and Holland, \{J. F.\}",

note = "Funding Information: ACKNOWLEDGEMENTS The cooperation of Drs. K. Rosemann, M. S. Wolff and Wm. Rom is greatfully acknowledged. Thanks are also due to Rogena Brown, Frances Camper, Suzan S. Gillman, Shirley Levine, Angeles Mison, Frances Perez and Robert Suzuki for technical assistance. We also greatfully acknowledge the excellent help and co-operation o€ the Marshfield Medical Foundation, Marshfield Medical Clinic in course of our Wisconsin clinical field survey. This research was supported by Center Grant for the National Institute of Environmental Health Sciences, ES00928 and by NCI Grant 5Pll-CA15936.",

year = "1979",

doi = "10.3109/01480547908993189",

language = "English",

volume = "2",

pages = "179--191",

journal = "Drug and Chemical Toxicology",

issn = "0148-0545",

publisher = "Taylor and Francis Ltd.",

number = "1-2",

}

TY - JOUR

T1 - Impaired immune function and identification of polybrominated biphenyls (PBB) in blood compartments of exposed michigan dairy farmers and chemical workers

AU - Bekesi, J. George

AU - Roboz, John

AU - Anderson, H. A.

AU - Roboz, Julia P.

AU - Fischbein, A. S.

AU - Selikoff, I. J.

AU - Holland, J. F.

N1 - Funding Information: ACKNOWLEDGEMENTS The cooperation of Drs. K. Rosemann, M. S. Wolff and Wm. Rom is greatfully acknowledged. Thanks are also due to Rogena Brown, Frances Camper, Suzan S. Gillman, Shirley Levine, Angeles Mison, Frances Perez and Robert Suzuki for technical assistance. We also greatfully acknowledge the excellent help and co-operation o€ the Marshfield Medical Foundation, Marshfield Medical Clinic in course of our Wisconsin clinical field survey. This research was supported by Center Grant for the National Institute of Environmental Health Sciences, ES00928 and by NCI Grant 5Pll-CA15936.

PY - 1979

Y1 - 1979

N2 - In 1973 PBB's were accidentally mixed into animal feed, resulting in marked toxic effects. Meat and dairy products were widely consumed in Michigan. To determine the impact of PBB's, 55 exposed Michigan farm residents, 11 Michigan chemical workers and 46 non-exposed Wisconsin farmers were examined. Abnormalities included decreased number of T-lymphocytes with concomitant increase of lymphocytes with no detectable surface markers, "null cells" and altered lymphocyte function. Data obtained from skin testing using standard recall antigens, showed no consistent correlation between the delayed cutaneous hypersensi-tivity response and the impaired lymphocyte function. PBB (hexa) in separated white blood cells and red cells was positively identified and quantified by gas chromatography-mass spectrometry. PBB and immu-nological abnormalities were not detected in non-exposed Wisconsin dairy farm residents.

AB - In 1973 PBB's were accidentally mixed into animal feed, resulting in marked toxic effects. Meat and dairy products were widely consumed in Michigan. To determine the impact of PBB's, 55 exposed Michigan farm residents, 11 Michigan chemical workers and 46 non-exposed Wisconsin farmers were examined. Abnormalities included decreased number of T-lymphocytes with concomitant increase of lymphocytes with no detectable surface markers, "null cells" and altered lymphocyte function. Data obtained from skin testing using standard recall antigens, showed no consistent correlation between the delayed cutaneous hypersensi-tivity response and the impaired lymphocyte function. PBB (hexa) in separated white blood cells and red cells was positively identified and quantified by gas chromatography-mass spectrometry. PBB and immu-nological abnormalities were not detected in non-exposed Wisconsin dairy farm residents.

UR - https://www.scopus.com/pages/publications/0018649273

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DO - 10.3109/01480547908993189

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AN - SCOPUS:0018649273

SN - 0148-0545

VL - 2

SP - 179

EP - 191

JO - Drug and Chemical Toxicology

JF - Drug and Chemical Toxicology

IS - 1-2

ER -

Impaired immune function and identification of polybrominated biphenyls (PBB) in blood compartments of exposed michigan dairy farmers and chemical workers

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