TY - JOUR
T1 - Impaired coronary vascular reactivity and functional capacity in women
T2 - Results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE) study
AU - Handberg, Eileen
AU - Johnson, B. Delia
AU - Arant, Christopher B.
AU - Wessel, Timothy R.
AU - Kerensky, Richard A.
AU - Von Mering, Gregory
AU - Olson, Marian B.
AU - Reis, Steven E.
AU - Shaw, Leslee
AU - Bairey Merz, C. Noel
AU - Sharaf, Barry L.
AU - Sopko, George
AU - Pepine, Carl J.
PY - 2006/2/7
Y1 - 2006/2/7
N2 - OBJECTIVES: We investigated the relationship between coronary vascular reactivity and functional capacity as assessed from the Duke Activity Status Index (DASI) in a cohort of women evaluated for suspected ischemia. BACKGROUND: Reduced functional capacity and impaired vascular reactivity are associated with poor prognosis, but an association between vascular reactivity and functional capacity is unknown. METHODS: A total of 190 women enrolled in the National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE) study had baseline clinical assessment and coronary artery flow velocity response to adenosine (CFVRado). We compared these results with self-reported DASI metabolic equivalents (METs). RESULTS: Mean age was 55 ± 11 years (range 21 to 83 years), and only 18% had coronary stenosis ≥50%. Women with a CFVRado <2.5 (n = 98) had mean DASI of 15.1 ± 13.6, compared to women (n = 92) with CFVRado ≥2.5, whose mean DASI was 21.0 ± 15.2 (p = 0.004). This relationship was maintained after adjusting for age and presence of coronary artery disease. CFVRado of ≥2.5 was associated with a DASI of >20 (odds ratio 3.03, 95% confidence interval 1.56 to 5.90, p = 0.001). CONCLUSIONS: Women with reduced CFVRado were significantly more likely to have reduced functional capacity. Impairment in coronary vascular function and reduced levels of activity may both play a role in the poorer prognosis observed in the WISE study women; however, the relationship between the two is still unclear.
AB - OBJECTIVES: We investigated the relationship between coronary vascular reactivity and functional capacity as assessed from the Duke Activity Status Index (DASI) in a cohort of women evaluated for suspected ischemia. BACKGROUND: Reduced functional capacity and impaired vascular reactivity are associated with poor prognosis, but an association between vascular reactivity and functional capacity is unknown. METHODS: A total of 190 women enrolled in the National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE) study had baseline clinical assessment and coronary artery flow velocity response to adenosine (CFVRado). We compared these results with self-reported DASI metabolic equivalents (METs). RESULTS: Mean age was 55 ± 11 years (range 21 to 83 years), and only 18% had coronary stenosis ≥50%. Women with a CFVRado <2.5 (n = 98) had mean DASI of 15.1 ± 13.6, compared to women (n = 92) with CFVRado ≥2.5, whose mean DASI was 21.0 ± 15.2 (p = 0.004). This relationship was maintained after adjusting for age and presence of coronary artery disease. CFVRado of ≥2.5 was associated with a DASI of >20 (odds ratio 3.03, 95% confidence interval 1.56 to 5.90, p = 0.001). CONCLUSIONS: Women with reduced CFVRado were significantly more likely to have reduced functional capacity. Impairment in coronary vascular function and reduced levels of activity may both play a role in the poorer prognosis observed in the WISE study women; however, the relationship between the two is still unclear.
UR - http://www.scopus.com/inward/record.url?scp=31644444880&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2005.10.023
DO - 10.1016/j.jacc.2005.10.023
M3 - Article
C2 - 16458171
AN - SCOPUS:31644444880
SN - 0735-1097
VL - 47
SP - S44-S49
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 3 SUPPL.
ER -