@article{bf28dc6de14c4a21ae0bebda6b1ff8ef,
title = "Impaired adult myelination in the prefrontal cortex of socially isolated mice",
abstract = "Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.",
author = "Jia Liu and Karen Dietz and Deloyht, {Jacqueline M.} and Xiomara Pedre and Dipti Kelkar and Jasbir Kaur and Vincent Vialou and Lobo, {Mary Kay} and Dietz, {David M.} and Nestler, {Eric J.} and Jeffrey Dupree and Patrizia Casaccia",
note = "Funding Information: We thank A. Sharp, P. Garg and J. Huynh for help with statistical analysis and multiple correction tests. This work was funded by the US National Institutes of Health (R37-NS42925-10 to P.C. and P50-MH96890 to E.J.N.), a Center core grant to the Virginia Commonwealth University Microscopy Facility (5P30NS047463) and the National Multiple Sclerosis Society (FG1874-A-1 to J.L.).",
year = "2012",
month = dec,
doi = "10.1038/nn.3263",
language = "English",
volume = "15",
pages = "1621--1623",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",
}