Impaired adult myelination in the prefrontal cortex of socially isolated mice

Jia Liu, Karen Dietz, Jacqueline M. Deloyht, Xiomara Pedre, Dipti Kelkar, Jasbir Kaur, Vincent Vialou, Mary Kay Lobo, David M. Dietz, Eric J. Nestler, Jeffrey Dupree, Patrizia Casaccia

Research output: Contribution to journalArticlepeer-review

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Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.

Original languageEnglish
Pages (from-to)1621-1623
Number of pages3
JournalNature Neuroscience
Issue number12
StatePublished - Dec 2012


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