@article{2d29957aad09481898306629a50b75d4,
title = "Impact of vitamin D supplementation on adiposity in African-Americans",
abstract = "BACKGROUND: African-Americans have higher rates of obesity-associated chronic diseases. Serum 25-hydroxyvitamin D (25(OH)D) shows an inverse association with obesity status. We investigated whether vitamin D supplementation changes body mass index (BMI). SUBJECTS: In total, 328 overweight African-Americans were enrolled over three consecutive winter periods (2007-2010) into a randomized, double-blind, placebo-controlled trial to receive cholecalciferol supplementation (0, 1000 international units (IU), 2000 IU or 4000 IU per day) for 3 months. Plasma concentrations of 25(OH)D and anthropometric measurements were done at baseline, 3 and 6 months. RESULTS: At 3 months, vitamin D supplementation in three dose groups (1000 IU, 2000 IU or 4000 IU per day) did not cause any significant changes in BMI as compared with placebo group 3-month change in BMI per 1000 IU per day estimate (SE): 0.01 (0.039); P = 0.78. CONCLUSIONS: In overweight African-Americans, short-term high-dose vitamin D supplementation did not alter BMI.",
author = "Chandler, {P. D.} and Scott, {J. B.} and Drake, {B. F.} and K. Ng and Chan, {A. T.} and Hollis, {B. W.} and Emmons, {K. M.} and Giovannucci, {E. L.} and Fuchs, {C. S.} and Bennett, {G. G.}",
note = "Funding Information: We would like to thank Cara Marcus, MSLIS, AHIP, Director of Library Services, Brigham and Women{\textquoteright}s Faulkner Hospital for facilitating access to reference articles and Harvard Catalyst for statistical support. The authors{\textquoteright} responsibilities were as follows—CSF, ELG, KME, BFD, GGB: conceived and designed the study; PDC CSF ELG: analyzed the study; and all authors contributed to the manuscript. This trial was funded by the National Cancer Institute (P50CA127003; K07CA148894 [Ng]; K22CA126992; 5K05CA124415 [Emmons]; U01CA138962 [Chandler]), the Department of Defense Prostate Cancer Research Program (PC081669 [Drake]), the American Society of Clinical Oncology Career Development Award (Ng) and Pharmavite LLC. The sponsor had no role in designing, developing the protocol, or conducting the trial; in data collection, analysis, management, or interpretation of the data; or in preparing the manuscript.",
year = "2015",
month = jan,
day = "1",
doi = "10.1038/nutd.2014.44",
language = "English",
volume = "5",
journal = "Nutrition and Diabetes",
issn = "2044-4052",
publisher = "Nature Publishing Group",
number = "1",
}