Impact of small bowel exploration using video-capsule endoscopy in the management of acute gastrointestinal graft-versus-host disease

Ibrahim Yakoub-Agha, Vincent Maunoury, Agnés Wacrenier, Sandrine Couignoux, Stéphane Depil, Pierre Desreumaux, Francis Bauters, Jean Frédéric Colombel, Jean Pierre Jouet

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53 Scopus citations

Abstract

Background. The purpose of this study was to evaluate the impact of the global diagnostic approach on the outcome of patients suspected of having acute (a) gastrointestinal (GI) graft-versus-host disease (GVHD). Methods. Ten consecutive patients with suspected aGI-GVHD were prospectively explored with an exhaustive approach including video-capsule endoscopy (VCE). Images observed with VCE were compared with results obtained with other GI investigations including duodenal biopsies. Results. Five patients had a normal VCE examination: four were successfully treated symptomatically, but one died as a result of toxoplasmosis. VCE disclosed aGI-GVHD lesions in all five remaining patients, and two of the five were considered normal by upper GI endoscopy. All of these patients experienced improvement in their GI symptoms within 2 weeks of adjustments to their immunosuppressive treatment. Conclusions. This approach has enhanced the authors' ability to adapt immunosuppressive treatments in patients suffering from suspected aGI- GVHD. Further investigation of the apparently high negative predictive value of VCE will be of great interest, particularly with a view to avoiding unnecessary immunosuppressive treatment.

Original languageEnglish
Pages (from-to)1697-1701
Number of pages5
JournalTransplantation
Volume78
Issue number11
DOIs
StatePublished - 15 Dec 2004
Externally publishedYes

Keywords

  • Acute gastrointestinal graft-versus-host disease
  • Allogeneic stem-cell transplantation
  • Video-capsule endoscopy

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