Impact of prenatal COVID-19 vaccination on delivery and neonatal outcomes: Results from a New York City cohort

Erona Ibroci, Xiaoqin Liu, Whitney Lieb, Rebecca Jessel, Frederieke A.J. Gigase, Kyle Chung, Mara Graziani, Molly Lieber, Sophie Ohrn, Jezelle Lynch, Juliana Castro, Christina Marshall, Rushna Tubassum, Farida Mutawakil, Elianna T. Kaplowitz, Sascha Ellington, Nina Molenaar, Rhoda S. Sperling, Elizabeth A. Howell, Teresa JanevicSiobhan M. Dolan, Joanne Stone, Lotje D. De Witte, Veerle Bergink, Anna Sophie Rommel

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Research suggest prenatal vaccination against coronavirus disease-19 (COVID-19) is safe. However, previous studies utilized retrospectively collected data or examined late pregnancy vaccinations. We investigated the associations of COVID-19 vaccination throughout pregnancy with delivery and neonatal outcomes. We included 1,794 mother-neonate dyads enrolled in the Generation C Study with known prenatal COVID-19 vaccination status and complete covariate and outcome data. We used multivariable quantile regressions to estimate the effect of prenatal COVID-19 vaccination on birthweight, delivery gestational age, and blood loss at delivery; and Poisson generalized linear models for Caesarean delivery (CD) and Neonatal Intensive Care Unit (NICU) admission. Using the above methods, we estimated effects of trimester of vaccine initiation on these outcomes. In our sample, 13.7% (n = 250) received at least one prenatal dose of any COVID-19 vaccine. Vaccination was not associated with birthweight (β = 12.42 g [-90.5, 114.8]), gestational age (β = 0.2 days [-1.1, 1.5]), blood loss (β = -50.6 ml [-107.0, 5.8]), the risks of CD (RR = 0.8; [0.6, 1.1]) or NICU admission (RR = 0.9 [0.5, 1.7]). Trimester of vaccine initiation was also not associated with these outcomes. Our findings suggest that there is no associated risk between prenatal COVID-19 vaccination and adverse delivery and neonatal outcomes in a cohort sample from NYC.

Original languageEnglish
Pages (from-to)649-656
Number of pages8
Issue number3
StatePublished - 16 Jan 2023


  • COVID-19
  • COVID-19 vaccine
  • Delivery
  • Neonatal
  • Pregnancy
  • mRNA vaccine


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