Impact of platelet glycoprotein IIb/IIIa receptor inhibitors on outcomes of diabetic patients undergoing percutaneous coronary interventions using sirolimus-eluting stents

Objective: We assessed the outcomes in diabetic patients undergoing percutaneous coronary intervention (PCI) using sirolimus-eluting stents (SES) as a function of treatment with glycoprotein (GP) llb/llla inhibitors. Methods and Results: Of 551 diabetic patients treated with a SES in nine trials (RAVEL, SIRIUS, E-SIRIUS, C-SIRIUS, REALITY, SVELTE, DIRECT, SIRIUS 2.25, and SIRIUS 4.0), 187 patients (33.9%) were administered GP llb/llla inhibitors during PCI. GP llb/llla blockade was associated with lower rates of myocardial infarction (Ml) at 30 days (1.1% vs. 3.3%, P = 0.12) and at 1 year (1.1% vs. 4.7%, P = 0.04), and composite endpoint of cardiac death/Ml at 1 year (2.2% vs. 6.2%, P = 0.05). Benefit from GP llb/llla inhibitors was confined to 128 insulin-treated diabetics who had remarkable reduction in Ml (0.0% vs. 6.3%, P = 0.04) and cardiac death/Ml at 30 days (0.0% vs. 7.6%, P = 0.05) and at 1-year (0.0% vs. 13.4%, P = 0.01 and 0.0% vs. 15.7%, P = 0.0005, respectively). When treated with GP llb/llla inhibitors, insulin-requiring diabetics had similar rates of 1-year death/Ml when compared with the nondiabetic patients (0% vs. 4.7%, P = 0.13, respectively). There were no significant differences in outcomes as a function of GP llb/llla blockade in diabetics not treated with insulin. Conclusion: In this analysis, outcomes of insulin requiring diabetic patients undergoing PCI with SES were considerably improved with adjunctive GP llb/llla inhibitors by decreasing the rates of Ml and composite endpoint of cardiac death/Ml.