Impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients with acute gastrointestinal bleeding: an international multicenter study

Yuhang Yin, Fanpu Ji, Fernando Gomes Romeiro, Mingyu Sun, Qiang Zhu, Dapeng Ma, Shanshan Yuan, Yingli He, Xiaofeng Liu, Cyriac Abby Philips, Nahum Méndez-Sánchez, Metin Basaranoglu, Kanokwan Pinyopornpanish, Yiling Li, Yunhai Wu, Yu Chen, Ling Yang, Lichun Shao, Andrea Mancuso, Frank TackeSu Lin, Bimin Li, Lei Liu, Xingshun Qi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Peptic ulcer is the most common source of non-variceal bleeding. However, it remains controversial whether the outcomes of cirrhotic patients with peptic ulcer bleeding differ from those with variceal bleeding. Methods: Cirrhotic patients with acute gastrointestinal bleeding (AGIB) who underwent endoscopy and had an identifiable source of bleeding were retrospectively screened from an international multicenter cohort. Logistic regression analyses were performed to explore the impact of peptic ulcer bleeding on in-hospital death and 5-day failure to control bleeding. Propensity score matching (PSM) analysis was performed by matching age, gender, Child-Pugh score, and model for end-stage liver disease score between the peptic ulcer bleeding and variceal bleeding groups. Results: Overall, 1535 patients were included, of whom 73 (4.7%) had peptic ulcer bleeding. Multivariate logistic regression analyses showed that peptic ulcer bleeding was not independently associated with in-hospital death (OR = 2.169, p = 0.126) or 5-day failure to control bleeding (OR = 1.230, p = 0.680). PSM analyses demonstrated that both in-hospital mortality (9.7% vs. 6.3%, p = 0.376) and rate of 5-day failure to control bleeding (6.9% vs. 5.4%, p = 0.787) were not significantly different between the two groups. Conclusions: The impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients is similar to that of variceal bleeding.

Original languageEnglish
JournalExpert Review of Gastroenterology and Hepatology
DOIs
StateAccepted/In press - 2024
Externally publishedYes

Keywords

  • gastrointestinal bleeding
  • Liver cirrhosis
  • peptic ulcer
  • prognosis
  • variceal bleeding

Fingerprint

Dive into the research topics of 'Impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients with acute gastrointestinal bleeding: an international multicenter study'. Together they form a unique fingerprint.

Cite this