Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation

C. Matthias Wilk; Isabel Weber; Kati Seidl; Carole Rachmühl; Anne Holzmann-Bürgel; Antonia M.S. Müller; Stefan P. Kuster; Urs Schanz; Annelies S. Zinkernagel

doi:10.1016/j.ijantimicag.2017.08.008

Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation

C. Matthias Wilk, Isabel Weber, Kati Seidl, Carole Rachmühl, Anne Holzmann-Bürgel, Antonia M.S. Müller, Stefan P. Kuster, Urs Schanz, Annelies S. Zinkernagel

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P < 0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.

Original language	English
Pages (from-to)	726-729
Number of pages	4
Journal	International Journal of Antimicrobial Agents
Volume	50
Issue number	6
DOIs	https://doi.org/10.1016/j.ijantimicag.2017.08.008
State	Published - Dec 2017
Externally published	Yes

Keywords

Decolonisation
Gut decontamination
Haematopoietic stem cell transplantation
Infection
Staphylococcus aureus

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10.1016/j.ijantimicag.2017.08.008

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Wilk, C. M., Weber, I., Seidl, K., Rachmühl, C., Holzmann-Bürgel, A., Müller, A. M. S., Kuster, S. P., Schanz, U., & Zinkernagel, A. S. (2017). Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation. International Journal of Antimicrobial Agents, 50(6), 726-729. https://doi.org/10.1016/j.ijantimicag.2017.08.008

@article{6a726d72dc6f4acfbabc45c5cfcbb4b2,

title = "Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation",

abstract = "Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P < 0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.",

keywords = "Decolonisation, Gut decontamination, Haematopoietic stem cell transplantation, Infection, Staphylococcus aureus",

author = "Wilk, {C. Matthias} and Isabel Weber and Kati Seidl and Carole Rachm{\"u}hl and Anne Holzmann-B{\"u}rgel and M{\"u}ller, {Antonia M.S.} and Kuster, {Stefan P.} and Urs Schanz and Zinkernagel, {Annelies S.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V. and International Society of Chemotherapy",

year = "2017",

month = dec,

doi = "10.1016/j.ijantimicag.2017.08.008",

language = "English",

volume = "50",

pages = "726--729",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

publisher = "Elsevier B.V.",

number = "6",

}

Wilk, CM, Weber, I, Seidl, K, Rachmühl, C, Holzmann-Bürgel, A, Müller, AMS, Kuster, SP, Schanz, U & Zinkernagel, AS 2017, 'Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation', International Journal of Antimicrobial Agents, vol. 50, no. 6, pp. 726-729. https://doi.org/10.1016/j.ijantimicag.2017.08.008

TY - JOUR

T1 - Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation

AU - Wilk, C. Matthias

AU - Weber, Isabel

AU - Seidl, Kati

AU - Rachmühl, Carole

AU - Holzmann-Bürgel, Anne

AU - Müller, Antonia M.S.

AU - Kuster, Stefan P.

AU - Schanz, Urs

AU - Zinkernagel, Annelies S.

PY - 2017/12

Y1 - 2017/12

N2 - Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P < 0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.

AB - Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P < 0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.

KW - Decolonisation

KW - Gut decontamination

KW - Haematopoietic stem cell transplantation

KW - Infection

KW - Staphylococcus aureus

UR - http://www.scopus.com/inward/record.url?scp=85033446394&partnerID=8YFLogxK

U2 - 10.1016/j.ijantimicag.2017.08.008

DO - 10.1016/j.ijantimicag.2017.08.008

M3 - Article

C2 - 28797807

AN - SCOPUS:85033446394

SN - 0924-8579

VL - 50

SP - 726

EP - 729

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 6

ER -

Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation

Abstract

Keywords

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