Impact of obesity on outcomes in a multiethnic cohort of medical intensive care unit patients

Vrinda Trivedi, Raymonde E. Jean, Frank Genese, Katherine A. Fuhrmann, Anjeet K. Saini, Van Derick Mangulabnan, Chirag Bavishi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Purpose: To examine the association of obesity with in-hospital mortality and complications during critical illness. Methods: We performed a retrospective analysis of a multiethnic cohort of 699 patients admitted to medical intensive care unit between January 2010 and May 2011 at Mount Sinai St. Luke’s and Mount Sinai West Hospitals, tertiary care centers in New York City. Multivariate logistic regression analysis was used to evaluate the association between obesity (body mass index [BMI] ≥ 30] and in-hospital mortality. Subgroup analysis was performed in elderly patients (age ≥65 years). Results: Compared to normal BMI, obese patients had lower in-hospital mortality (24.4% vs 17.6%, P ¼.04). On multivariate analysis, obesity was independently associated with lower in-hospital mortality (odds ratio [OR]: 0.49, 95% confidence interval [CI]: 0.27-0.89, P ¼.018). There was no significant difference in rates of mechanical ventilation, reintubation, and vasopressor requirement across BMI categories. In subgroup analysis, elderly obese patients did not display lower in-hospital mortality (adjusted OR: 0.85, 95% CI: 0.40-1.82, P ¼. 68). Conclusion: Our study supports the hypothesis that obesity is associated with decreased mortality during critical illness. However, this finding was not observed among elderly obese patients. Further studies should explore the interaction between age, obesity, and outcomes in critical illness.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalJournal of Intensive Care Medicine
Volume33
Issue number2
DOIs
StatePublished - 1 Feb 2018
Externally publishedYes

Keywords

  • BMI
  • Critical illness
  • Hospital mortality
  • Obesity

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