Impact of obesity in patients infected with 2009 influenza A(H1N1)

Emili Díaz; Alejandro Rodríguez; Ignacio Martin-Loeches; Leonardo Lorente; María Del Mar Martín; Juan Carlos Pozo; Juan Carlos Montejo; Angel Estella; Ángel Arenzana; Jordi Rello; Pedro Cobo; Javier Martins; Cecilia Carbayo; Emilio Robles-Musso; Antonio Cárdenas; Javier Fierro; Ocaña Fernández; Rafael Sierra; Ma Jesús Huertos; R. Guerrero; Enrique Márquez; Manuel Rodríguez-Carvajal; Antonio Jareño; José Pomares; José Luis Ballesteros; Yolanda Fernández; Francisco Lobato; José F. Prieto; José Albofedo-Sánchez; Pilar Martínez; Miguel Angel Díaz Castellanos; Guillermo Sevilla; José Garnacho-Montero; Rafael Hinojosa; Esteban Fernández; Ana Loza; Cristóbal León; Dolores Ocaña; Manuel Luis Avellanas; Arantxa Lander; S. Garrido Ramírez De Arellano; M. I.Marquina Lacueva; Pilar Luque; Ignacio González; Jose Ma Montón; Jose Ma Díaz; Pilar López-Reina; Sergio Sáez; Lisardo Iglesias; Carmen Pascual González; Quiroga; Águeda García-Rodríguez; Lorenzo Socias; Pedro Ibánez; Marcío Borges-Sa; A. Socias; A. Del Castillo; Ricard Jordà Marcos; José M. Bonell; Ignacio Amestarán; Sergio Ruiz-Santana; Juan José Díaz; Sisón; David Hernández; Ana Trujillo; Luis Regalado; Mar Martín; Sergio Martínez; J. J. Cáceres; Borja Suberviola; P. Ugarte; Fernando García-López; Angel Álvaro Alonso; Antonio Pasilla; Ma Luisa Gómez Grande; Antonio Albaya; Alfonso Canabal; Luis Marina; Juan B.López Messa; Ma Jesús López Pueyo; Zulema Ferreras; Santiago Macias; José Ángel Berezo; Jesús Blanco Varela; Ojeda A. Andaluz; Antonio Álvarez Terrero; Fabiola Tena Ezpeleta; Rosa Ma Catalán; Miquel Ferrer; Antoni Torres; Sandra Barbadillo; Lluís Cabré; Assumpta Rovira; Francisco Álvarez-Lerma; Antonia Vázquez; Joan Nolla; Francisco Fernández; Joaquim Ramón Cervelló; Rafael Mañéz; J. Ballús; Rosa Ma Granada; Jordi Vallés; Marta Ortíz; C. Guía; Fernando Arméstar; Joaquim Páez; Jordi Almirall; Xavier Balanzo; Elena Arnau; Lluis Llopart; Mercedes Palomar; Iñaki Catalán; Josep Ma Sirvent; Cristina Ferri; Nerea López De Arbina; Mariona Badía; Montserrat Valverdú-Vidal; Fernando Barcenilla; Mònica Magret; M. F. Esteban; José Luna; Juan Ma Nava; J. González De Molina; Zoran Josic; Francisco Gurri; Thiago Lisboa; Diego De Mendoza; Sandra Trefler; Alberto Fernández-Zapata; Teresa Recio; Abilio Arrascaeta; Ma José García-Ramos; Elena Gallego; F. Bueno; Ma Lourdes Cordero; José A. Pastor; Luis Álvarez-Rocha; Dolores Vila; Ana Díaz Lamas; Javier Blanco Pérez; M. Ortiz Piquer; Eleuterio Merayo; Victor Jose López-Ciudad; Juan Cortez; Eva Vilaboy; Eva Maria Saborido; Raul José González; Santiago Freita; José Luis Monzón; Félix Goñi; Frutos Del Nogal Sáez; M. Blasco Navalpotro; Ma Carmen García-Torrejón; César Pérez-Calvo; Diego López; Luis Arnaiz; S. Sánchez-Alonso; Carlos Velayos; Francisco Del Río; Miguel Ángel González; María Cruz Martín; José Ma Molina; Patricia Albert; Ana De Pablo; José Eugenio Guerrero; Jaime Benitez Peyrat; José A. Juliá; Enrique Cerdá; Manuel Alvarez; Carlos Pey; Montse Rodríguez; Eduardo Palencia; Rafael Caballero; Rafael Guerrero; Concepción Vaquero; Francisco Mariscal; S. García; Almudena Simón; Nieves Carrasco; Isidro Prieto; A. Liétor; R. Ramos; Beatríz Galván; Juan C. Figueira; M. Cruz Soriano; P. Galdós; Bárbara Balandin Moreno; Fernández Del Cabo; Cecilia Hermosa; Federico Gordo; Alejandro Algora; Amparo Paredes; J. A. Cambronero; Sonia Gómez-Rosado; Sofía Martínez; F. Felices Abad; Mariano Martinez; Sergio Manuel Butí; Gil Rueda; Francisco García; Laura Macaya; Enrique Maraví-Poma; I. Jimenez Urra; L. Macaya Redin; A. Tellería; Josu Insansti; Nagore González; Pilar Marco; Loreto Vidaur; B. Santamaría; Juan Carlos Vergara; Jose Ramon Iruretagoyena Amiano; Alberto Manzano; Carlos Castillo Arenal; José Blanquer; Roberto Reig Valero; A. Belenger; Susana Altaba; Bernabé Álvarez-Sánchez; Santiago Alberto Picos; Ángel Sánchez-Miralles; Juan Bonastre; M. Palamo; Javier Cebrian; José Cuñat; Belén Romero; Rafael Zaragoza; Virgilio Paricio; Asunción Marques; S. Sánchez-Morcillo; S. Tormo; J. Latour; M. Ángel García

doi:10.1378/chest.10-1160

Impact of obesity in patients infected with 2009 influenza A(H1N1)

Emili Díaz, Alejandro Rodríguez, Ignacio Martin-Loeches, Leonardo Lorente, María Del Mar Martín, Juan Carlos Pozo, Juan Carlos Montejo, Angel Estella, Ángel Arenzana, Jordi Rello, Pedro Cobo, Javier Martins, Cecilia Carbayo, Emilio Robles-Musso, Antonio Cárdenas, Javier Fierro, Ocaña Fernández, Rafael Sierra, Ma Jesús Huertos, R. GuerreroEnrique Márquez, Manuel Rodríguez-Carvajal, Antonio Jareño, José Pomares, José Luis Ballesteros, Yolanda Fernández, Francisco Lobato, José F. Prieto, José Albofedo-Sánchez, Pilar Martínez, Miguel Angel Díaz Castellanos, Guillermo Sevilla, José Garnacho-Montero, Rafael Hinojosa, Esteban Fernández, Ana Loza, Cristóbal León, Dolores Ocaña, Manuel Luis Avellanas, Arantxa Lander, S. Garrido Ramírez De Arellano, M. I.Marquina Lacueva, Pilar Luque, Ignacio González, Jose Ma Montón, Jose Ma Díaz, Pilar López-Reina, Sergio Sáez, Lisardo Iglesias, Carmen Pascual González, Quiroga, Águeda García-Rodríguez, Lorenzo Socias, Pedro Ibánez, Marcío Borges-Sa, A. Socias, A. Del Castillo, Ricard Jordà Marcos, José M. Bonell, Ignacio Amestarán, Sergio Ruiz-Santana, Juan José Díaz, Sisón, David Hernández, Ana Trujillo, Luis Regalado, Mar Martín, Sergio Martínez, J. J. Cáceres, Borja Suberviola, P. Ugarte, Fernando García-López, Angel Álvaro Alonso, Antonio Pasilla, Ma Luisa Gómez Grande, Antonio Albaya, Alfonso Canabal, Luis Marina, Juan B.López Messa, Ma Jesús López Pueyo, Zulema Ferreras, Santiago Macias, José Ángel Berezo, Jesús Blanco Varela, Ojeda A. Andaluz, Antonio Álvarez Terrero, Fabiola Tena Ezpeleta, Rosa Ma Catalán, Miquel Ferrer, Antoni Torres, Sandra Barbadillo, Lluís Cabré, Assumpta Rovira, Francisco Álvarez-Lerma, Antonia Vázquez, Joan Nolla, Francisco Fernández, Joaquim Ramón Cervelló, Rafael Mañéz, J. Ballús, Rosa Ma Granada, Jordi Vallés, Marta Ortíz, C. Guía, Fernando Arméstar, Joaquim Páez, Jordi Almirall, Xavier Balanzo, Elena Arnau, Lluis Llopart, Mercedes Palomar, Iñaki Catalán, Josep Ma Sirvent, Cristina Ferri, Nerea López De Arbina, Mariona Badía, Montserrat Valverdú-Vidal, Fernando Barcenilla, Mònica Magret, M. F. Esteban, José Luna, Juan Ma Nava, J. González De Molina, Zoran Josic, Francisco Gurri, Thiago Lisboa, Diego De Mendoza, Sandra Trefler, Alberto Fernández-Zapata, Teresa Recio, Abilio Arrascaeta, Ma José García-Ramos, Elena Gallego, F. Bueno, Ma Lourdes Cordero, José A. Pastor, Luis Álvarez-Rocha, Dolores Vila, Ana Díaz Lamas, Javier Blanco Pérez, M. Ortiz Piquer, Eleuterio Merayo, Victor Jose López-Ciudad, Juan Cortez, Eva Vilaboy, Eva Maria Saborido, Raul José González, Santiago Freita, José Luis Monzón, Félix Goñi, Frutos Del Nogal Sáez, M. Blasco Navalpotro, Ma Carmen García-Torrejón, César Pérez-Calvo, Diego López, Luis Arnaiz, S. Sánchez-Alonso, Carlos Velayos, Francisco Del Río, Miguel Ángel González, María Cruz Martín, José Ma Molina, Patricia Albert, Ana De Pablo, José Eugenio Guerrero, Jaime Benitez Peyrat, José A. Juliá, Enrique Cerdá, Manuel Alvarez, Carlos Pey, Montse Rodríguez, Eduardo Palencia, Rafael Caballero, Rafael Guerrero, Concepción Vaquero, Francisco Mariscal, S. García, Almudena Simón, Nieves Carrasco, Isidro Prieto, A. Liétor, R. Ramos, Beatríz Galván, Juan C. Figueira, M. Cruz Soriano, P. Galdós, Bárbara Balandin Moreno, Fernández Del Cabo, Cecilia Hermosa, Federico Gordo, Alejandro Algora, Amparo Paredes, J. A. Cambronero, Sonia Gómez-Rosado, Sofía Martínez, F. Felices Abad, Mariano Martinez, Sergio Manuel Butí, Gil Rueda, Francisco García, Laura Macaya, Enrique Maraví-Poma, I. Jimenez Urra, L. Macaya Redin, A. Tellería, Josu Insansti, Nagore González, Pilar Marco, Loreto Vidaur, B. Santamaría, Juan Carlos Vergara, Jose Ramon Iruretagoyena Amiano, Alberto Manzano, Carlos Castillo Arenal, José Blanquer, Roberto Reig Valero, A. Belenger, Susana Altaba, Bernabé Álvarez-Sánchez, Santiago Alberto Picos, Ángel Sánchez-Miralles, Juan Bonastre, M. Palamo, Javier Cebrian, José Cuñat, Belén Romero, Rafael Zaragoza, Virgilio Paricio, Asunción Marques, S. Sánchez-Morcillo, S. Tormo, J. Latour, M. Ángel García

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Objective: A large proportion of patients infected with 2009 influenza A(H1N1)(A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality. Methods: This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A (H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI>30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P<.05 were considered significant. Results: In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI>40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P<.01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P =.02), had longer ICU length of stay(10.8 ± 12.1 days vs 13.7 ± 11.7 days, P=.03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P=.02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1;95% CI, 0.69-1.75; P=.68). Conclusions: In our cohort, patients who were obese and infected with A (H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.

Original language	English
Pages (from-to)	382-386
Number of pages	5
Journal	Chest
Volume	139
Issue number	2
DOIs	https://doi.org/10.1378/chest.10-1160
State	Published - 1 Feb 2011
Externally published	Yes

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10.1378/chest.10-1160

Cite this

Díaz, E., Rodríguez, A., Martin-Loeches, I., Lorente, L., Del Mar Martín, M., Pozo, J. C., Montejo, J. C., Estella, A., Arenzana, Á., Rello, J., Cobo, P., Martins, J., Carbayo, C., Robles-Musso, E., Cárdenas, A., Fierro, J., Fernández, O., Sierra, R., Huertos, M. J., ... García, M. Á. (2011). Impact of obesity in patients infected with 2009 influenza A(H1N1). Chest, 139(2), 382-386. https://doi.org/10.1378/chest.10-1160

@article{53e44510d96b47dab359fba195d80924,

title = "Impact of obesity in patients infected with 2009 influenza A(H1N1)",

abstract = "Objective: A large proportion of patients infected with 2009 influenza A(H1N1)(A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality. Methods: This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Espa{\~n}ola de Medicina Intensiva, Cr{\'i}tica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A (H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI>30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P<.05 were considered significant. Results: In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI>40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P<.01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P =.02), had longer ICU length of stay(10.8 ± 12.1 days vs 13.7 ± 11.7 days, P=.03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P=.02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1;95% CI, 0.69-1.75; P=.68). Conclusions: In our cohort, patients who were obese and infected with A (H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.",

author = "Emili D{\'i}az and Alejandro Rodr{\'i}guez and Ignacio Martin-Loeches and Leonardo Lorente and {Del Mar Mart{\'i}n}, Mar{\'i}a and Pozo, {Juan Carlos} and Montejo, {Juan Carlos} and Angel Estella and {\'A}ngel Arenzana and Jordi Rello and Pedro Cobo and Javier Martins and Cecilia Carbayo and Emilio Robles-Musso and Antonio C{\'a}rdenas and Javier Fierro and Oca{\~n}a Fern{\'a}ndez and Rafael Sierra and Huertos, {Ma Jes{\'u}s} and R. Guerrero and Enrique M{\'a}rquez and Manuel Rodr{\'i}guez-Carvajal and Antonio Jare{\~n}o and Jos{\'e} Pomares and Ballesteros, {Jos{\'e} Luis} and Yolanda Fern{\'a}ndez and Francisco Lobato and Prieto, {Jos{\'e} F.} and Jos{\'e} Albofedo-S{\'a}nchez and Pilar Mart{\'i}nez and Castellanos, {Miguel Angel D{\'i}az} and Guillermo Sevilla and Jos{\'e} Garnacho-Montero and Rafael Hinojosa and Esteban Fern{\'a}ndez and Ana Loza and Crist{\'o}bal Le{\'o}n and Dolores Oca{\~n}a and Avellanas, {Manuel Luis} and Arantxa Lander and {De Arellano}, {S. Garrido Ram{\'i}rez} and Lacueva, {M. I.Marquina} and Pilar Luque and Ignacio Gonz{\'a}lez and Mont{\'o}n, {Jose Ma} and D{\'i}az, {Jose Ma} and Pilar L{\'o}pez-Reina and Sergio S{\'a}ez and Lisardo Iglesias and Gonz{\'a}lez, {Carmen Pascual} and Quiroga and {\'A}gueda Garc{\'i}a-Rodr{\'i}guez and Lorenzo Socias and Pedro Ib{\'a}nez and Marc{\'i}o Borges-Sa and A. Socias and {Del Castillo}, A. and Marcos, {Ricard Jord{\`a}} and Bonell, {Jos{\'e} M.} and Ignacio Amestar{\'a}n and Sergio Ruiz-Santana and D{\'i}az, {Juan Jos{\'e}} and Sis{\'o}n and David Hern{\'a}ndez and Ana Trujillo and Luis Regalado and Mar Mart{\'i}n and Sergio Mart{\'i}nez and C{\'a}ceres, {J. J.} and Borja Suberviola and P. Ugarte and Fernando Garc{\'i}a-L{\'o}pez and Alonso, {Angel {\'A}lvaro} and Antonio Pasilla and Grande, {Ma Luisa G{\'o}mez} and Antonio Albaya and Alfonso Canabal and Luis Marina and Messa, {Juan B.L{\'o}pez} and Pueyo, {Ma Jes{\'u}s L{\'o}pez} and Zulema Ferreras and Santiago Macias and Berezo, {Jos{\'e} {\'A}ngel} and Varela, {Jes{\'u}s Blanco} and Andaluz, {Ojeda A.} and Terrero, {Antonio {\'A}lvarez} and Ezpeleta, {Fabiola Tena} and Catal{\'a}n, {Rosa Ma} and Miquel Ferrer and Antoni Torres and Sandra Barbadillo and Llu{\'i}s Cabr{\'e} and Assumpta Rovira and Francisco {\'A}lvarez-Lerma and Antonia V{\'a}zquez and Joan Nolla and Francisco Fern{\'a}ndez and Cervell{\'o}, {Joaquim Ram{\'o}n} and Rafael Ma{\~n}{\'e}z and J. Ball{\'u}s and Granada, {Rosa Ma} and Jordi Vall{\'e}s and Marta Ort{\'i}z and C. Gu{\'i}a and Fernando Arm{\'e}star and Joaquim P{\'a}ez and Jordi Almirall and Xavier Balanzo and Elena Arnau and Lluis Llopart and Mercedes Palomar and I{\~n}aki Catal{\'a}n and Sirvent, {Josep Ma} and Cristina Ferri and {De Arbina}, {Nerea L{\'o}pez} and Mariona Bad{\'i}a and Montserrat Valverd{\'u}-Vidal and Fernando Barcenilla and M{\`o}nica Magret and Esteban, {M. F.} and Jos{\'e} Luna and Nava, {Juan Ma} and {De Molina}, {J. Gonz{\'a}lez} and Zoran Josic and Francisco Gurri and Thiago Lisboa and {De Mendoza}, Diego and Sandra Trefler and Alberto Fern{\'a}ndez-Zapata and Teresa Recio and Abilio Arrascaeta and Garc{\'i}a-Ramos, {Ma Jos{\'e}} and Elena Gallego and F. Bueno and Cordero, {Ma Lourdes} and Pastor, {Jos{\'e} A.} and Luis {\'A}lvarez-Rocha and Dolores Vila and Lamas, {Ana D{\'i}az} and P{\'e}rez, {Javier Blanco} and Piquer, {M. Ortiz} and Eleuterio Merayo and L{\'o}pez-Ciudad, {Victor Jose} and Juan Cortez and Eva Vilaboy and Saborido, {Eva Maria} and Gonz{\'a}lez, {Raul Jos{\'e}} and Santiago Freita and Monz{\'o}n, {Jos{\'e} Luis} and F{\'e}lix Go{\~n}i and S{\'a}ez, {Frutos Del Nogal} and Navalpotro, {M. Blasco} and Garc{\'i}a-Torrej{\'o}n, {Ma Carmen} and C{\'e}sar P{\'e}rez-Calvo and Diego L{\'o}pez and Luis Arnaiz and S. S{\'a}nchez-Alonso and Carlos Velayos and {Del R{\'i}o}, Francisco and Gonz{\'a}lez, {Miguel {\'A}ngel} and Mart{\'i}n, {Mar{\'i}a Cruz} and Molina, {Jos{\'e} Ma} and Patricia Albert and {De Pablo}, Ana and Guerrero, {Jos{\'e} Eugenio} and Peyrat, {Jaime Benitez} and Juli{\'a}, {Jos{\'e} A.} and Enrique Cerd{\'a} and Manuel Alvarez and Carlos Pey and Montse Rodr{\'i}guez and Eduardo Palencia and Rafael Caballero and Rafael Guerrero and Concepci{\'o}n Vaquero and Francisco Mariscal and S. Garc{\'i}a and Almudena Sim{\'o}n and Nieves Carrasco and Isidro Prieto and A. Li{\'e}tor and R. Ramos and Beatr{\'i}z Galv{\'a}n and Figueira, {Juan C.} and Soriano, {M. Cruz} and P. Gald{\'o}s and Moreno, {B{\'a}rbara Balandin} and {Del Cabo}, Fern{\'a}ndez and Cecilia Hermosa and Federico Gordo and Alejandro Algora and Amparo Paredes and Cambronero, {J. A.} and Sonia G{\'o}mez-Rosado and Sof{\'i}a Mart{\'i}nez and Abad, {F. Felices} and Mariano Martinez and But{\'i}, {Sergio Manuel} and Gil Rueda and Francisco Garc{\'i}a and Laura Macaya and Enrique Marav{\'i}-Poma and Urra, {I. Jimenez} and Redin, {L. Macaya} and A. Teller{\'i}a and Josu Insansti and Nagore Gonz{\'a}lez and Pilar Marco and Loreto Vidaur and B. Santamar{\'i}a and Vergara, {Juan Carlos} and Amiano, {Jose Ramon Iruretagoyena} and Alberto Manzano and Arenal, {Carlos Castillo} and Jos{\'e} Blanquer and Valero, {Roberto Reig} and A. Belenger and Susana Altaba and Bernab{\'e} {\'A}lvarez-S{\'a}nchez and Picos, {Santiago Alberto} and {\'A}ngel S{\'a}nchez-Miralles and Juan Bonastre and M. Palamo and Javier Cebrian and Jos{\'e} Cu{\~n}at and Bel{\'e}n Romero and Rafael Zaragoza and Virgilio Paricio and Asunci{\'o}n Marques and S. S{\'a}nchez-Morcillo and S. Tormo and J. Latour and Garc{\'i}a, {M. {\'A}ngel}",

year = "2011",

month = feb,

day = "1",

doi = "10.1378/chest.10-1160",

language = "English",

volume = "139",

pages = "382--386",

journal = "Chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians",

number = "2",

}

Díaz, E, Rodríguez, A, Martin-Loeches, I, Lorente, L, Del Mar Martín, M, Pozo, JC, Montejo, JC, Estella, A, Arenzana, Á, Rello, J, Cobo, P, Martins, J, Carbayo, C, Robles-Musso, E, Cárdenas, A, Fierro, J, Fernández, O, Sierra, R, Huertos, MJ, Guerrero, R, Márquez, E, Rodríguez-Carvajal, M, Jareño, A, Pomares, J, Ballesteros, JL, Fernández, Y, Lobato, F, Prieto, JF, Albofedo-Sánchez, J, Martínez, P, Castellanos, MAD, Sevilla, G, Garnacho-Montero, J, Hinojosa, R, Fernández, E, Loza, A, León, C, Ocaña, D, Avellanas, ML, Lander, A, De Arellano, SGR, Lacueva, MIM, Luque, P, González, I, Montón, JM, Díaz, JM, López-Reina, P, Sáez, S, Iglesias, L, González, CP, Quiroga, García-Rodríguez, Á, Socias, L, Ibánez, P, Borges-Sa, M, Socias, A, Del Castillo, A, Marcos, RJ, Bonell, JM, Amestarán, I, Ruiz-Santana, S, Díaz, JJ, Sisón, Hernández, D, Trujillo, A, Regalado, L, Martín, M, Martínez, S, Cáceres, JJ, Suberviola, B, Ugarte, P, García-López, F, Alonso, AÁ, Pasilla, A, Grande, MLG, Albaya, A, Canabal, A, Marina, L, Messa, JBL, Pueyo, MJL, Ferreras, Z, Macias, S, Berezo, JÁ, Varela, JB, Andaluz, OA, Terrero, AÁ, Ezpeleta, FT, Catalán, RM, Ferrer, M, Torres, A, Barbadillo, S, Cabré, L, Rovira, A, Álvarez-Lerma, F, Vázquez, A, Nolla, J, Fernández, F, Cervelló, JR, Mañéz, R, Ballús, J, Granada, RM, Vallés, J, Ortíz, M, Guía, C, Arméstar, F, Páez, J, Almirall, J, Balanzo, X, Arnau, E, Llopart, L, Palomar, M, Catalán, I, Sirvent, JM, Ferri, C, De Arbina, NL, Badía, M, Valverdú-Vidal, M, Barcenilla, F, Magret, M, Esteban, MF, Luna, J, Nava, JM, De Molina, JG, Josic, Z, Gurri, F, Lisboa, T, De Mendoza, D, Trefler, S, Fernández-Zapata, A, Recio, T, Arrascaeta, A, García-Ramos, MJ, Gallego, E, Bueno, F, Cordero, ML, Pastor, JA, Álvarez-Rocha, L, Vila, D, Lamas, AD, Pérez, JB, Piquer, MO, Merayo, E, López-Ciudad, VJ, Cortez, J, Vilaboy, E, Saborido, EM, González, RJ, Freita, S, Monzón, JL, Goñi, F, Sáez, FDN, Navalpotro, MB, García-Torrejón, MC, Pérez-Calvo, C, López, D, Arnaiz, L, Sánchez-Alonso, S, Velayos, C, Del Río, F, González, MÁ, Martín, MC, Molina, JM, Albert, P, De Pablo, A, Guerrero, JE, Peyrat, JB, Juliá, JA, Cerdá, E, Alvarez, M, Pey, C, Rodríguez, M, Palencia, E, Caballero, R, Guerrero, R, Vaquero, C, Mariscal, F, García, S, Simón, A, Carrasco, N, Prieto, I, Liétor, A, Ramos, R, Galván, B, Figueira, JC, Soriano, MC, Galdós, P, Moreno, BB, Del Cabo, F, Hermosa, C, Gordo, F, Algora, A, Paredes, A, Cambronero, JA, Gómez-Rosado, S, Martínez, S, Abad, FF, Martinez, M, Butí, SM, Rueda, G, García, F, Macaya, L, Maraví-Poma, E, Urra, IJ, Redin, LM, Tellería, A, Insansti, J, González, N, Marco, P, Vidaur, L, Santamaría, B, Vergara, JC, Amiano, JRI, Manzano, A, Arenal, CC, Blanquer, J, Valero, RR, Belenger, A, Altaba, S, Álvarez-Sánchez, B, Picos, SA, Sánchez-Miralles, Á, Bonastre, J, Palamo, M, Cebrian, J, Cuñat, J, Romero, B, Zaragoza, R, Paricio, V, Marques, A, Sánchez-Morcillo, S, Tormo, S, Latour, J & García, MÁ 2011, 'Impact of obesity in patients infected with 2009 influenza A(H1N1)', Chest, vol. 139, no. 2, pp. 382-386. https://doi.org/10.1378/chest.10-1160

TY - JOUR

T1 - Impact of obesity in patients infected with 2009 influenza A(H1N1)

AU - Díaz, Emili

AU - Rodríguez, Alejandro

AU - Martin-Loeches, Ignacio

AU - Lorente, Leonardo

AU - Del Mar Martín, María

AU - Pozo, Juan Carlos

AU - Montejo, Juan Carlos

AU - Estella, Angel

AU - Arenzana, Ángel

AU - Rello, Jordi

AU - Cobo, Pedro

AU - Martins, Javier

AU - Carbayo, Cecilia

AU - Robles-Musso, Emilio

AU - Cárdenas, Antonio

AU - Fierro, Javier

AU - Fernández, Ocaña

AU - Sierra, Rafael

AU - Huertos, Ma Jesús

AU - Guerrero, R.

AU - Márquez, Enrique

AU - Rodríguez-Carvajal, Manuel

AU - Jareño, Antonio

AU - Pomares, José

AU - Ballesteros, José Luis

AU - Fernández, Yolanda

AU - Lobato, Francisco

AU - Prieto, José F.

AU - Albofedo-Sánchez, José

AU - Martínez, Pilar

AU - Castellanos, Miguel Angel Díaz

AU - Sevilla, Guillermo

AU - Garnacho-Montero, José

AU - Hinojosa, Rafael

AU - Fernández, Esteban

AU - Loza, Ana

AU - León, Cristóbal

AU - Ocaña, Dolores

AU - Avellanas, Manuel Luis

AU - Lander, Arantxa

AU - De Arellano, S. Garrido Ramírez

AU - Lacueva, M. I.Marquina

AU - Luque, Pilar

AU - González, Ignacio

AU - Montón, Jose Ma

AU - Díaz, Jose Ma

AU - López-Reina, Pilar

AU - Sáez, Sergio

AU - Iglesias, Lisardo

AU - González, Carmen Pascual

AU - Quiroga,

AU - García-Rodríguez, Águeda

AU - Socias, Lorenzo

AU - Ibánez, Pedro

AU - Borges-Sa, Marcío

AU - Socias, A.

AU - Del Castillo, A.

AU - Marcos, Ricard Jordà

AU - Bonell, José M.

AU - Amestarán, Ignacio

AU - Ruiz-Santana, Sergio

AU - Díaz, Juan José

AU - Sisón,

AU - Hernández, David

AU - Trujillo, Ana

AU - Regalado, Luis

AU - Martín, Mar

AU - Martínez, Sergio

AU - Cáceres, J. J.

AU - Suberviola, Borja

AU - Ugarte, P.

AU - García-López, Fernando

AU - Alonso, Angel Álvaro

AU - Pasilla, Antonio

AU - Grande, Ma Luisa Gómez

AU - Albaya, Antonio

AU - Canabal, Alfonso

AU - Marina, Luis

AU - Messa, Juan B.López

AU - Pueyo, Ma Jesús López

AU - Ferreras, Zulema

AU - Macias, Santiago

AU - Berezo, José Ángel

AU - Varela, Jesús Blanco

AU - Andaluz, Ojeda A.

AU - Terrero, Antonio Álvarez

AU - Ezpeleta, Fabiola Tena

AU - Catalán, Rosa Ma

AU - Ferrer, Miquel

AU - Torres, Antoni

AU - Barbadillo, Sandra

AU - Cabré, Lluís

AU - Rovira, Assumpta

AU - Álvarez-Lerma, Francisco

AU - Vázquez, Antonia

AU - Nolla, Joan

AU - Fernández, Francisco

AU - Cervelló, Joaquim Ramón

AU - Mañéz, Rafael

AU - Ballús, J.

AU - Granada, Rosa Ma

AU - Vallés, Jordi

AU - Ortíz, Marta

AU - Guía, C.

AU - Arméstar, Fernando

AU - Páez, Joaquim

AU - Almirall, Jordi

AU - Balanzo, Xavier

AU - Arnau, Elena

AU - Llopart, Lluis

AU - Palomar, Mercedes

AU - Catalán, Iñaki

AU - Sirvent, Josep Ma

AU - Ferri, Cristina

AU - De Arbina, Nerea López

AU - Badía, Mariona

AU - Valverdú-Vidal, Montserrat

AU - Barcenilla, Fernando

AU - Magret, Mònica

AU - Esteban, M. F.

AU - Luna, José

AU - Nava, Juan Ma

AU - De Molina, J. González

AU - Josic, Zoran

AU - Gurri, Francisco

AU - Lisboa, Thiago

AU - De Mendoza, Diego

AU - Trefler, Sandra

AU - Fernández-Zapata, Alberto

AU - Recio, Teresa

AU - Arrascaeta, Abilio

AU - García-Ramos, Ma José

AU - Gallego, Elena

AU - Bueno, F.

AU - Cordero, Ma Lourdes

AU - Pastor, José A.

AU - Álvarez-Rocha, Luis

AU - Vila, Dolores

AU - Lamas, Ana Díaz

AU - Pérez, Javier Blanco

AU - Piquer, M. Ortiz

AU - Merayo, Eleuterio

AU - López-Ciudad, Victor Jose

AU - Cortez, Juan

AU - Vilaboy, Eva

AU - Saborido, Eva Maria

AU - González, Raul José

AU - Freita, Santiago

AU - Monzón, José Luis

AU - Goñi, Félix

AU - Sáez, Frutos Del Nogal

AU - Navalpotro, M. Blasco

AU - García-Torrejón, Ma Carmen

AU - Pérez-Calvo, César

AU - López, Diego

AU - Arnaiz, Luis

AU - Sánchez-Alonso, S.

AU - Velayos, Carlos

AU - Del Río, Francisco

AU - González, Miguel Ángel

AU - Martín, María Cruz

AU - Molina, José Ma

AU - Albert, Patricia

AU - De Pablo, Ana

AU - Guerrero, José Eugenio

AU - Peyrat, Jaime Benitez

AU - Juliá, José A.

AU - Cerdá, Enrique

AU - Alvarez, Manuel

AU - Pey, Carlos

AU - Rodríguez, Montse

AU - Palencia, Eduardo

AU - Caballero, Rafael

AU - Guerrero, Rafael

AU - Vaquero, Concepción

AU - Mariscal, Francisco

AU - García, S.

AU - Simón, Almudena

AU - Carrasco, Nieves

AU - Prieto, Isidro

AU - Liétor, A.

AU - Ramos, R.

AU - Galván, Beatríz

AU - Figueira, Juan C.

AU - Soriano, M. Cruz

AU - Galdós, P.

AU - Moreno, Bárbara Balandin

AU - Del Cabo, Fernández

AU - Hermosa, Cecilia

AU - Gordo, Federico

AU - Algora, Alejandro

AU - Paredes, Amparo

AU - Cambronero, J. A.

AU - Gómez-Rosado, Sonia

AU - Martínez, Sofía

AU - Abad, F. Felices

AU - Martinez, Mariano

AU - Butí, Sergio Manuel

AU - Rueda, Gil

AU - García, Francisco

AU - Macaya, Laura

AU - Maraví-Poma, Enrique

AU - Urra, I. Jimenez

AU - Redin, L. Macaya

AU - Tellería, A.

AU - Insansti, Josu

AU - González, Nagore

AU - Marco, Pilar

AU - Vidaur, Loreto

AU - Santamaría, B.

AU - Vergara, Juan Carlos

AU - Amiano, Jose Ramon Iruretagoyena

AU - Manzano, Alberto

AU - Arenal, Carlos Castillo

AU - Blanquer, José

AU - Valero, Roberto Reig

AU - Belenger, A.

AU - Altaba, Susana

AU - Álvarez-Sánchez, Bernabé

AU - Picos, Santiago Alberto

AU - Sánchez-Miralles, Ángel

AU - Bonastre, Juan

AU - Palamo, M.

AU - Cebrian, Javier

AU - Cuñat, José

AU - Romero, Belén

AU - Zaragoza, Rafael

AU - Paricio, Virgilio

AU - Marques, Asunción

AU - Sánchez-Morcillo, S.

AU - Tormo, S.

AU - Latour, J.

AU - García, M. Ángel

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Objective: A large proportion of patients infected with 2009 influenza A(H1N1)(A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality. Methods: This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A (H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI>30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P<.05 were considered significant. Results: In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI>40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P<.01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P =.02), had longer ICU length of stay(10.8 ± 12.1 days vs 13.7 ± 11.7 days, P=.03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P=.02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1;95% CI, 0.69-1.75; P=.68). Conclusions: In our cohort, patients who were obese and infected with A (H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.

AB - Objective: A large proportion of patients infected with 2009 influenza A(H1N1)(A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality. Methods: This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A (H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI>30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P<.05 were considered significant. Results: In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI>40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P<.01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P =.02), had longer ICU length of stay(10.8 ± 12.1 days vs 13.7 ± 11.7 days, P=.03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P=.02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1;95% CI, 0.69-1.75; P=.68). Conclusions: In our cohort, patients who were obese and infected with A (H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.

UR - http://www.scopus.com/inward/record.url?scp=79551591901&partnerID=8YFLogxK

U2 - 10.1378/chest.10-1160

DO - 10.1378/chest.10-1160

M3 - Article

AN - SCOPUS:79551591901

SN - 0012-3692

VL - 139

SP - 382

EP - 386

JO - Chest

JF - Chest

IS - 2

ER -

Impact of obesity in patients infected with 2009 influenza A(H1N1)

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