Impact of gender on in-hospital outcomes in patients with Takotsubo syndrome: A nationwide analysis from 2006 to 2014

Alejandro Lemor, Alvaro J. Ramos-Rodriguez, Ricardo De La Villa, Seyed H. Hosseini Dehkordi, Fernando Vazquez de Lara, Shawn Lee, Mario Rodriguez Rivera, Abel Casso Dominguez, Edgar Argulian

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: Takotsubo syndrome (TTS) is characterized by acute, transient systolic dysfunction of the left ventricle not attributed to coronary artery disease (CAD). Hypothesis: There are differences in hospital outcomes in patients admitted with TTS based on their gender. Methods: The National Inpatient Sample database was searched for patients admitted with a principal diagnosis of TTS from 2006 to 2014 using the ICD9-CM code 429.83. Using Pearson's χ 2 and Student's t test analyses, the P-value was calculated for differences among baseline characteristics of patients. Multivariate regression models were then created to adjust for potential confounders. Results: A total of 39 662 admissions with TTS were identified, 91.7% female and 8.3% male with mean age of 66.5 and 61.6 years, respectively. The incidence of TTS increased progressively from 2006 to 2014. Female patients were more likely to have hypertension, hypothyroidism, or depression. Males were more likely to use tobacco, or have known CAD. Males had almost 4-fold higher probability of in-hospital mortality compared to females (3.7% vs 1.1%; P<0.001). Certain complications including cardiogenic shock, ventricular fibrillation/tachycardia, and acute kidney injury were more common in males. Conclusions: There are distinct gender differences in clinical characteristics of patients admitted with TTS. Although TTS is more common in females, it is associated with higher morbidity and mortality in males.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalClinical Cardiology
Volume42
Issue number1
DOIs
StatePublished - Jan 2019
Externally publishedYes

Keywords

  • Takotsubo
  • gender
  • stress-induced cardiomyopathy

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