TY - JOUR
T1 - Impact of gender on in-hospital outcomes in patients with Takotsubo syndrome
T2 - A nationwide analysis from 2006 to 2014
AU - Lemor, Alejandro
AU - Ramos-Rodriguez, Alvaro J.
AU - De La Villa, Ricardo
AU - Hosseini Dehkordi, Seyed H.
AU - Vazquez de Lara, Fernando
AU - Lee, Shawn
AU - Rodriguez Rivera, Mario
AU - Casso Dominguez, Abel
AU - Argulian, Edgar
N1 - Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2019/1
Y1 - 2019/1
N2 - Background: Takotsubo syndrome (TTS) is characterized by acute, transient systolic dysfunction of the left ventricle not attributed to coronary artery disease (CAD). Hypothesis: There are differences in hospital outcomes in patients admitted with TTS based on their gender. Methods: The National Inpatient Sample database was searched for patients admitted with a principal diagnosis of TTS from 2006 to 2014 using the ICD9-CM code 429.83. Using Pearson's χ 2 and Student's t test analyses, the P-value was calculated for differences among baseline characteristics of patients. Multivariate regression models were then created to adjust for potential confounders. Results: A total of 39 662 admissions with TTS were identified, 91.7% female and 8.3% male with mean age of 66.5 and 61.6 years, respectively. The incidence of TTS increased progressively from 2006 to 2014. Female patients were more likely to have hypertension, hypothyroidism, or depression. Males were more likely to use tobacco, or have known CAD. Males had almost 4-fold higher probability of in-hospital mortality compared to females (3.7% vs 1.1%; P<0.001). Certain complications including cardiogenic shock, ventricular fibrillation/tachycardia, and acute kidney injury were more common in males. Conclusions: There are distinct gender differences in clinical characteristics of patients admitted with TTS. Although TTS is more common in females, it is associated with higher morbidity and mortality in males.
AB - Background: Takotsubo syndrome (TTS) is characterized by acute, transient systolic dysfunction of the left ventricle not attributed to coronary artery disease (CAD). Hypothesis: There are differences in hospital outcomes in patients admitted with TTS based on their gender. Methods: The National Inpatient Sample database was searched for patients admitted with a principal diagnosis of TTS from 2006 to 2014 using the ICD9-CM code 429.83. Using Pearson's χ 2 and Student's t test analyses, the P-value was calculated for differences among baseline characteristics of patients. Multivariate regression models were then created to adjust for potential confounders. Results: A total of 39 662 admissions with TTS were identified, 91.7% female and 8.3% male with mean age of 66.5 and 61.6 years, respectively. The incidence of TTS increased progressively from 2006 to 2014. Female patients were more likely to have hypertension, hypothyroidism, or depression. Males were more likely to use tobacco, or have known CAD. Males had almost 4-fold higher probability of in-hospital mortality compared to females (3.7% vs 1.1%; P<0.001). Certain complications including cardiogenic shock, ventricular fibrillation/tachycardia, and acute kidney injury were more common in males. Conclusions: There are distinct gender differences in clinical characteristics of patients admitted with TTS. Although TTS is more common in females, it is associated with higher morbidity and mortality in males.
KW - Takotsubo
KW - gender
KW - stress-induced cardiomyopathy
UR - http://www.scopus.com/inward/record.url?scp=85060411852&partnerID=8YFLogxK
U2 - 10.1002/clc.23109
DO - 10.1002/clc.23109
M3 - Article
C2 - 30393886
AN - SCOPUS:85060411852
SN - 0160-9289
VL - 42
SP - 13
EP - 18
JO - Clinical Cardiology
JF - Clinical Cardiology
IS - 1
ER -