Impact of filovirus infection upon cellular signaling pathways

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The members of the filoviridae family, Ebola virus and Marburg virus, are among the most lethal viral pathogens of humans and nonhuman primates. Filoviral disease is manifested by dysregulated innate and adaptive immune responses and a clinical syndrome similar to disseminated intravascular coagulation. Several experimental vaccines havebeen produced which effectively protect rodents or nonhuman primates from lethal filovirus disease. However, a licensed vaccine or therapy is not presently available for human use. An understanding of the molecular pathways activated or manipulated by these viruses should provide insights into the severe disease induced by filoviruses and may also provide a key for the identification of new therapeutic targets. Here, we describe what is known about how filoviruses modulate cell signal transduction pathways and discuss how these pathways influence filovirus pathogenesis. Particular focus will be on the impact of the Ebola virus proteins VP35 and VP24 upon the host interferon response and the impact of the Ebola virus glycoprotein (GP) upon MAP kinase signaling and upon the expression of proteins at the cell surface.

Original languageEnglish
Title of host publicationRNA Viruses
Subtitle of host publicationHost Gene Responses to Infections
PublisherWorld Scientific Publishing Co.
Number of pages26
ISBN (Electronic)9789812833808
ISBN (Print)981283379X, 9789812833792
StatePublished - 1 Jan 2009


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