The members of the filoviridae family, Ebola virus and Marburg virus, are among the most lethal viral pathogens of humans and nonhuman primates. Filoviral disease is manifested by dysregulated innate and adaptive immune responses and a clinical syndrome similar to disseminated intravascular coagulation. Several experimental vaccines havebeen produced which effectively protect rodents or nonhuman primates from lethal filovirus disease. However, a licensed vaccine or therapy is not presently available for human use. An understanding of the molecular pathways activated or manipulated by these viruses should provide insights into the severe disease induced by filoviruses and may also provide a key for the identification of new therapeutic targets. Here, we describe what is known about how filoviruses modulate cell signal transduction pathways and discuss how these pathways influence filovirus pathogenesis. Particular focus will be on the impact of the Ebola virus proteins VP35 and VP24 upon the host interferon response and the impact of the Ebola virus glycoprotein (GP) upon MAP kinase signaling and upon the expression of proteins at the cell surface.
|Title of host publication||RNA Viruses|
|Subtitle of host publication||Host Gene Responses to Infections|
|Publisher||World Scientific Publishing Co.|
|Number of pages||26|
|ISBN (Print)||981283379X, 9789812833792|
|State||Published - 1 Jan 2009|