Impact of Diabetes Mellitus on Ischemic Events in Men and Women After Percutaneous Coronary Intervention

Serdar Farhan, Usman Baber, Birgit Vogel, Melissa Aquino, Jaya Chandrasekhar, Michela Faggioni, Gennaro Giustino, Alexandra Kautzky-Willer, Joesph Sweeny, Srushti Shah, Pooja Vijay, Nitin Barman, Pedro Moreno, Jason Kovacic, George Dangas, Annapoorna Kini, Roxana Mehran, Samin Sharma

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Studies have shown worse outcome for women compared with men after percutaneous coronary intervention (PCI), especially in the presence of diabetes mellitus (DM). We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single-center PCI registry enrolled from January 2009 to December 2014 were categorized accordingly: female/non-DM, female/DM, male/non-DM, and male/DM. End points included death and myocardial infarction (MI) at 1 year. Of the overall population, 15% (n = 2,631) were female/non-DM, 17% (n = 2,891) were female/DM, 38% (n = 6,483) were male/non-DM, and 30% (n = 5,149) were male/DM. Within the 4 study groups, female/DM had the highest risk, whereas female/non-DM and male/DM showed similar risks and male/non-DM showed lowest risk for death (4.64% vs 3.08% vs 2.93% vs 2.31%; p-trend <0.0001 over all groups and p = 0.69 between female/non-DM and male/DM, respectively) and MI (4.15% vs 3.99% vs 3.71% vs 2.55%; p trend <0.0001 over all groups and p = 0.97 between female/non-DM and male/DM, respectively). After multivariate adjustment findings were largely unchanged suggesting highest risk for adverse events in diabetic women compared with other groups and comparable risks for death and MI in nondiabetic women compared with diabetic men. In conclusion, these findings highlight the combined influence of DM and female gender as strong determinants of post-PCI risk while also illustrating “risk equivalence” between nondiabetic women versus diabetic men.

Original languageEnglish
Pages (from-to)1166-1172
Number of pages7
JournalAmerican Journal of Cardiology
Volume119
Issue number8
DOIs
StatePublished - 15 Apr 2017

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