Impact of Atopic Dermatitis Lesion Location on Quality of Life in Adult Patients in a Real-world Study

Background: Atopic dermatitis (AD) has a negative impact on patients’ quality of life (QoL). Objective: To report the impact of specific AD lesion locations on QoL in adult patients with AD using real-world data. Methods: The Adelphi US Disease Specific Programme was conducted between January–April 2018. Physicians documented patient demographics/characteristics, AD lesion locations, and body surface area; patients completed questionnaires reporting the impact of lesion locations on QoL. Results: AD severity was moderate in 51.6% of patients and severe in 6.0%. Lesions were commonly identified in more than one location. All AD lesion locations impacted QoL. Visible areas were most bothersome, including head/neck (68%), hands/fingers (58%), front (30%), upper extremities (22%), and lower extremities (16%), with statistically significant associations for a number of Dermatology _with Life _those Quality _{that are} Index _most (DLQI) _{visible/accessible.} items. Itch, soreness, _Lesions pain, _{onDo the} and _{head/neck Not} stinging_Copy are _and also _{hands/fingers} associated _(58%) with a _demonstrated number of body _an areas _increased but in _impact particular _on^the Conclusions: ^{anxiety and} In ^depression patients with ^dimension AD, quality ^{of the} of life ^EuroQol was^Penalties most ^5-Dimension affected in ^tool. patients ^Apply with lesions in visible areas, including head/neck, hands/ fingers, and upper extremities, with statistically significant associations for a number of DLQI domains. Physicians should be aware of the burden of AD lesions on QoL and consider having conversations with patients to better understand the impact of these lesions. Prior presentation: 28th Annual European Academy of Dermatology and Venereology Congress; 9–13 October 2019, Madrid, Spain. Poster number P0233.