TY - JOUR
T1 - Impact of Anastomotic Leakage After Colorectal Cancer Surgery on Quality of Life
T2 - A Systematic Review
AU - On behalf of the CoReAL Collaborative
AU - Gielen, Anke H.C.
AU - Heuvelings, Danique J.I.
AU - Sylla, Patricia
AU - Van Loon, Yu Ting
AU - Melenhorst, Jarno
AU - Bouvy, Nicole D.
AU - Kimman, Merel L.
AU - Breukink, Stephanie O.
AU - Adamina, Michel
AU - Mahdi Al-Taher, Alberto Arezzo
AU - Arulampalam, Tan
AU - Balvardi, Saba
AU - Bhatt, Himani
AU - Botti, Marta
AU - Boutros, Marylise
AU - Clark, David A.
AU - Daams, Freek
AU - Davids, Jennifer S.
AU - De Sadeleer, Anse
AU - Fingerhut, Abe
AU - Francis, Nader
AU - Garoufalia, Zoe
AU - Hompes, Roel
AU - Hyman, Neil H.
AU - Jafari, Mehraneh D.
AU - Jenkins, John T.
AU - Jongen, Audrey C.H.M.
AU - Keller, Deborah S.
AU - Lai, Samuel H.
AU - Lefevre, Jérémie H.
AU - Martens, Bibi
AU - Maykel, Justin A.
AU - Moon, Jeongyoon
AU - Okomoto, Nariaki
AU - Paquette, Ian
AU - Pellino, Gianluca
AU - Shawki, Sherief F.
AU - Shogan, Benjamin D.
AU - Selvasekar, Chelliah
AU - Siu Man, Simon N.G.
AU - Stijns, Jasper
AU - Tejedor, Patricia
AU - Chen, William Tzu Liang
AU - Leij, Christiaan van Der
AU - Wexner, Steven D.
AU - Wick, Elizabeth
AU - Yiasemidou, Marina
N1 - Publisher Copyright:
Copyright © 2024 The Author(s).
PY - 2025/2/1
Y1 - 2025/2/1
N2 - BACKGROUND: Colorectal anastomotic leakage remains one of the most frequent and dreaded postoperative complications after colorectal resection. However, limited research has been conducted on the impact of this complication on the quality of life of patients who have undergone colorectal cancer surgery. OBJECTIVE: The aim of this systematic review was to identify, appraise, and synthesize the available evidence regarding the quality of life in patients with anastomotic leakage after oncological colorectal resections to inform clinical decision-making. DATA SOURCES AND STUDY SELECTION: PubMed, Embase, and the Cochrane Library were searched for studies reporting quality of life using validated questionnaires in patients with anastomotic leakage after oncological colorectal resections. The literature search was performed systematically and according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. OUTCOMES: Outcomes from quality-of-life questionnaires of patients with and without anastomotic leakage were analyzed. RESULTS: Thirteen articles reporting on 4618 individual patients were included, among which 527 patients developed anastomotic leakage. Quality of life was evaluated using 10 distinct questionnaires administered at various postoperative time points, ranging from 1 month to 14 years. Quality-of-life outcomes differed across studies and time points, but overall scores were most negatively affected by anastomotic leakage up to 12 months postoperatively. LIMITATIONS: There was a high heterogeneity between the included studies based on the questionnaires used and the time of assessment. CONCLUSIONS: The published evidence suggests that anastomotic leakage after oncologic colorectal resection is associated with impaired quality of life, especially within the first postoperative year. The impact of anastomotic leakage on quality of life warrants further evaluation and discussion with patients.
AB - BACKGROUND: Colorectal anastomotic leakage remains one of the most frequent and dreaded postoperative complications after colorectal resection. However, limited research has been conducted on the impact of this complication on the quality of life of patients who have undergone colorectal cancer surgery. OBJECTIVE: The aim of this systematic review was to identify, appraise, and synthesize the available evidence regarding the quality of life in patients with anastomotic leakage after oncological colorectal resections to inform clinical decision-making. DATA SOURCES AND STUDY SELECTION: PubMed, Embase, and the Cochrane Library were searched for studies reporting quality of life using validated questionnaires in patients with anastomotic leakage after oncological colorectal resections. The literature search was performed systematically and according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. OUTCOMES: Outcomes from quality-of-life questionnaires of patients with and without anastomotic leakage were analyzed. RESULTS: Thirteen articles reporting on 4618 individual patients were included, among which 527 patients developed anastomotic leakage. Quality of life was evaluated using 10 distinct questionnaires administered at various postoperative time points, ranging from 1 month to 14 years. Quality-of-life outcomes differed across studies and time points, but overall scores were most negatively affected by anastomotic leakage up to 12 months postoperatively. LIMITATIONS: There was a high heterogeneity between the included studies based on the questionnaires used and the time of assessment. CONCLUSIONS: The published evidence suggests that anastomotic leakage after oncologic colorectal resection is associated with impaired quality of life, especially within the first postoperative year. The impact of anastomotic leakage on quality of life warrants further evaluation and discussion with patients.
KW - Anastomotic leakage
KW - Colorectal cancer surgery
KW - Quality of life
UR - https://www.scopus.com/pages/publications/85208258465
U2 - 10.1097/DCR.0000000000003478
DO - 10.1097/DCR.0000000000003478
M3 - Review article
AN - SCOPUS:85208258465
SN - 0012-3706
VL - 68
SP - 154
EP - 170
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
IS - 2
ER -