@article{8869987fc501479d8b99440afa099870,
title = "Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer{\textquoteright}s disease",
abstract = "Acid sphingomyelinase (ASM) has been implicated in neurodegenerative disease pathology, including Alzheimer{\textquoteright}s disease (AD). However, the specific role of plasma ASM in promoting these pathologies is poorly understood. Herein, we explore plasma ASM as a circulating factor that accelerates neuropathological features in AD by exposing young APP/PS1 mice to the blood of mice overexpressing ASM, through parabiotic surgery. Elevated plasma ASM was found to enhance several neuropathological features in the young APP/PS1 mice by mediating the differentiation of blood-derived, pathogenic Th17 cells. Antibody-based immunotherapy targeting plasma ASM showed efficient inhibition of ASM activity in the blood of APP/PS1 mice and, interestingly, led to prophylactic effects on neuropathological features by suppressing pathogenic Th17 cells. Our data reveals insights into the potential pathogenic mechanisms underlying AD and highlights ASM-targeting immunotherapy as a potential strategy for further investigation.",
author = "Choi, {Byung Jo} and Park, {Min Hee} and Park, {Kang Ho} and Han, {Wan Hui} and Yoon, {Hee Ji} and Jung, {Hye Yoon} and Hong, {Ju Yeon} and Chowdhury, {Md Riad} and Kim, {Kyung Yeol} and Jihoon Lee and Song, {Im Sook} and Minyeong Pang and Choi, {Min Koo} and Erich Gulbins and Martin Reichel and Johannes Kornhuber and Hong, {Chang Won} and Changho Kim and Kim, {Seung Hyun} and Schuchman, {Edward H.} and Jin, {Hee Kyung} and Bae, {Jae sung}",
note = "Funding Information: We particularly would like to thank Yu Sin Han, Eun Yeong Lim, and Yun Ju Park for technical assistance. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2018M3C7A1056513 to H.K.J, 2020R1A2C3006875 to J.S.B, 2020R1A2C3006734 to H.K.J, 2020R1A4A2002691 to H.K.J). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare and MSIT, Republic of Korea (HU20C0345 to J.S.B). Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41467-023-37316-z",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}